Characterization of the feline host range and a specific epitope of feline panleukopenia virus

Virology
U TruyenC R Parrish

Abstract

The feline parvovirus subgroup is comprised of viruses isolated from various carnivores, including the dog, cat, mink, raccoon, Arctic fox, and raccoon dog. Those viruses are > 98% identical in their DNA sequences and are very similar antigenically. We have shown that although canine parvovirus (CPV) replicates in numerous feline cell lines in vitro it does not infect cats after parenteral inoculation (U. Truyen and C. R. Parrish, (1992) J. Virol. 66, 5399-5408). Here we use recombination mapping to locate some viral determinants required for feline host range, and show that the ability to replicate in cats was determined by the right-hand 45% of the genome, most likely a function of the capsid protein gene. Efficient replication in the cat appeared to require feline panleukopenia virus sequences from both ends of the VP2 molecule, which contained differences of VP2 amino acid residues 80, 564, and 568. The difference at amino acid 80 was also associated with expression of an FPV-specific antigenic epitope. The differences which affected the feline host range were located in a region of the capsid structure where three VP2 molecules interact, and the mutations gave rise to changes in the conformation of loops of the three adjoi...Continue Reading

Citations

Sep 5, 2008·Journal of Virology·Karin HoelzerColin R Parrish
Oct 29, 2003·Journal of Virology·Lakshmanan GovindasamyMavis Agbandje-McKenna
Sep 13, 2005·Annual Review of Microbiology·Colin R Parrish, Yoshihiro Kawaoka
Apr 25, 2002·Emerging Infectious Diseases·Yasuhiro IkedaMasami Mochizuki
Aug 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Bärbel KaufmannMichael G Rossmann
Jan 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Laura A ShackeltonEdward C Holmes
Jul 9, 2016·The Journal of General Virology·Carla Miranda, Gertrude Thompson
Apr 1, 1994·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·U TruyenO R Kaaden
Mar 28, 2019·Proceedings. Biological Sciences·Abdelkader BehdennaMafalda Viana
Aug 30, 2008·The Journal of General Virology·Karin HoelzerEdward C Holmes
Apr 13, 1996·The Veterinary Record·U TruyenC R Parrish
Feb 1, 1995·Veterinary Microbiology·U TruyenO R Kaaden
Jun 28, 2001·Parasitology International·K NakagakiE Kanda
Mar 1, 1995·Baillière's Clinical Haematology·C R Parrish

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