Characterization of the first molluscicidal lipopolysaccharide from Moraxella osloensis.

Applied and Environmental Microbiology
L Tan, Parwinder S Grewal

Abstract

Moraxella osloensis is a bacterium that is mutualistically associated with Phasmarhabditis hermaphrodita, a nematode that has potential for the biocontrol of mollusk pests, especially the slug Deroceras reticulatum. We discovered that purified M. osloensis lipopolysaccharide (LPS) possesses a lethal toxicity to D. reticulatum when administered by injection but no contact or oral toxicity to this slug. The toxicity of the LPS resides in the lipid A moiety. M. osloensis LPS was semiquantitated at 6 x 10(7) endotoxin units per mg. The LPS is a rough-type LPS with an estimated molecular weight of 5,300. Coinjection of galactosamine with the LPS increased the LPS's toxicity to the slug two- to four-fold. The galactosamine-induced sensitization of the slug to the LPS was reversed completely by uridine.

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Jul 31, 2002·Applied and Environmental Microbiology·Li Tan, Parwinder S Grewal
Nov 1, 2002·Journal of Clinical Microbiology·Li Tan, Parwinder S Grewal

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Citations

Mar 27, 2015·Biophysical Journal·Björn M BurmannSebastian Hiller
Jun 1, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Nolwenn M DheillyFrédéric Thomas

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