Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase

Genetics
Gregory A ShanowerPaul Schedl

Abstract

We have identified a novel gene named grappa (gpp) that is the Drosophila ortholog of the Saccharomyces cerevisiae gene Dot1, a histone methyltransferase that modifies the lysine (K)79 residue of histone H3. gpp is an essential gene identified in a genetic screen for dominant suppressors of pairing-dependent silencing, a Polycomb-group (Pc-G)-mediated silencing mechanism necessary for the maintenance phase of Bithorax complex (BX-C) expression. Surprisingly, gpp mutants not only exhibit Pc-G phenotypes, but also display phenotypes characteristic of trithorax-group mutants. Mutations in gpp also disrupt telomeric silencing but do not affect centric heterochromatin. These apparent contradictory phenotypes may result from loss of gpp activity in mutants at sites of both active and inactive chromatin domains. Unlike the early histone H3 K4 and K9 methylation patterns, the appearance of methylated K79 during embryogenesis coincides with the maintenance phase of BX-C expression, suggesting that there is a unique role for this chromatin modification in development.

References

Aug 1, 1995·Molecular and Cellular Biology·G DeshpandeP Schedl
Jan 1, 1993·Cold Spring Harbor Symposia on Quantitative Biology·J VazquezM Galloni
May 13, 1998·Developmental Biology·T T SuP H O'Farrell
Mar 16, 2001·Current Opinion in Genetics & Development·H W Brock, M van Lohuizen
Mar 15, 2002·Current Opinion in Genetics & Development·Jeffrey A Simon, John W Tamkun
Jun 28, 2002·Cell·Fred van LeeuwenDaniel E Gottschling
Jul 5, 2002·The Journal of Biological Chemistry·Nicolas LacosteJacques Côte
Aug 2, 2002·Nature·Scott D BriggsBrian D Strahl
Feb 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Huck Hui NgKevin Struhl
Feb 27, 2003·The Journal of Biological Chemistry·Hogune ImEmery H Bresnick
Nov 18, 2003·Annual Review of Genetics·Laura A Lee, Terry L Orr-Weaver
Jan 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Erin McKittrickSteven Henikoff

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Citations

Mar 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nicole BüttnerTanja Vogel
May 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Martha C Castaño BetancourtJoyce B J van Meurs
Feb 24, 2006·Molecular Biology of the Cell·Julio VazquezJohn W Sedat
Nov 6, 2012·Genes & Development·Tasuku KitadaMichael Grunstein
Jul 5, 2011·Genes & Development·Anh Tram Nguyen, Yi Zhang
Apr 12, 2012·Molecular and Cellular Biology·José M AntãoRobert E Kingston
Mar 31, 2010·Molecular and Cellular Biology·Purnima SinghPiroska E Szabó
Feb 21, 2008·Molecular and Cellular Biology·David J StegerChristopher R Vakoc
Dec 16, 2005·Molecular and Cellular Biology·Karen AdelmanJohn T Lis
Feb 28, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Krassimir Yankulov
Feb 5, 2011·Epigenetics & Chromatin·Iris Je StulemeijerFred van Leeuwen
Dec 6, 2008·PloS One·J Greg DohenyThomas A Grigliatti
Sep 7, 2005·Genetics·Harald BiessmannJames M Mason
Dec 4, 2012·International Journal of Molecular Sciences·Shisheng Li
May 13, 2014·Cell and Tissue Research·Deborah Roidl, Christine Hacker
May 24, 2014·Leukemia·C M McLeanF van Leeuwen
Jan 6, 2016·Chromosoma·Hanneke Vlaming, Fred van Leeuwen
Jul 25, 2009·The EMBO Journal·Stefan Schoeftner, Maria A Blasco
Dec 24, 2011·Acta Biochimica Et Biophysica Sinica·Xi ZhangXiaobing Shi
Jun 30, 2015·Experimental Hematology·Chun-Wei Chen, Scott A Armstrong
Sep 18, 2007·Biochimie·Alexandre OttavianiFrédérique Magdinier
Dec 2, 2014·Cell Reports·David A OrlandoMatthew G Guenther
Mar 3, 2018·Biomolecules·Katherine WoodShona Murphy
Jul 6, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Anja EbertGunter Reuter
Dec 18, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·James M MasonHarald Biessmann
Aug 12, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Harald BiessmannJames M Mason
Aug 29, 2006·Nature Reviews. Molecular Cell Biology·Abbie SaundersJohn T Lis
Mar 17, 2010·Expert Opinion on Therapeutic Targets·Evan R BarryTheodore P Rasmussen
Jul 26, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Luan WenYun-Bo Shi
Nov 5, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Luan WenYun-Bo Shi
Jan 19, 2011·Chembiochem : a European Journal of Chemical Biology·Floor FrederiksFred van Leeuwen

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