Characterization of the gut microbiota of Kawasaki disease patients by metagenomic analysis

Frontiers in Microbiology
Akiko KinumakiMakoto Kuroda

Abstract

Kawasaki disease (KD) is an acute febrile illness of early childhood. Previous reports have suggested that genetic disease susceptibility factors, together with a triggering infectious agent, could be involved in KD pathogenesis; however, the precise etiology of this disease remains unknown. Additionally, previous culture-based studies have suggested a possible role of intestinal microbiota in KD pathogenesis. In this study, we performed metagenomic analysis to comprehensively assess the longitudinal variation in the intestinal microbiota of 28 KD patients. Several notable bacterial genera were commonly extracted during the acute phase, whereas a relative increase in the number of Ruminococcus bacteria was observed during the non-acute phase of KD. The metagenomic analysis results based on bacterial species classification suggested that the number of sequencing reads with similarity to five Streptococcus spp. (S. pneumonia, pseudopneumoniae, oralis, gordonii, and sanguinis), in addition to patient-derived Streptococcus isolates, markedly increased during the acute phase in most patients. Streptococci include a variety of pathogenic bacteria and probiotic bacteria that promote human health; therefore, this further species discri...Continue Reading

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Citations

Aug 6, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Patrick Coit, Amr H Sawalha
Feb 23, 2019·Modern Rheumatology·Mitsuhiro AkiyamaTsutomu Takeuchi
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Oct 10, 2021·Pediatric Research·Akihito TakeuchiTakashi Yorifuji

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Datasets Mentioned

BETA
DRA000895
DRA001171

Methods Mentioned

BETA
Illumina Sequencing
PCA

Software Mentioned

BWA
Illumina base - calling pipeline
BLAST
RAST
MEGAN
R prcomp
LEfSe
MEGA
SW
MiSeq

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