PMID: 8602366Feb 1, 1996Paper

Characterization of the highly divergent U2 RNA homolog in the microsporidian Vairimorpha necatrix

Nucleic Acids Research
P DiMariaC R Vossbrinck

Abstract

An RNA homologous to U2 RNA and a single copy gene encoding the RNA homolog have been characterized in the microsporidian, Vairimorpha necatrix. The RNA which is 165 nucleotides in length possesses significant similarity to U2 RNA, particularly in the 5' half of the molecule. The U2 homolog contains the highly conserved GUAGUA branch point binding sequence seen in all U2 RNAs except those of the trypanosomes. A U2 RNA sequence element implicated in a U2:U6 RNA intermolecular pairing is also present in the U2 homolog. The V. necatrix U2 RNA homolog differs at positions previously found to be invariant in U2 RNAs and appears to lack an Sm binding site sequence. The RNA can be folded into a secondary structure possessing three of the four principal stem-loops proposed for the consensus U2 RNA structure. A cis-diol containing cap structure is present at the 5' end of the U2 homolog. Unlike the cap structures seen in U-snRNAs and mRNAs it is neither 2,2,7-trimethylguanosine, gamma-monomethyl phosphate, nor 7-methylguanosine.

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Citations

Feb 13, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C P Vivarès, G Méténier
Jul 19, 2000·International Journal for Parasitology·A Mathis
May 23, 2001·Microbes and Infection·G Méténier, C P Vivarès
Jan 1, 1997·Nucleic Acids Research·J Gu, R Reddy
Jul 12, 2005·Folia Parasitologica·Charles R Vossbrinck, Bettina A Debrunner-Vossbrinck
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·D G BreckenridgeM N Schnare
Jan 23, 1999·Current Opinion in Genetics & Development·J M Logsdon
Jul 27, 2002·Annual Review of Microbiology·Patrick J Keeling, Naomi M Fast

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