Characterization of the human analogue of a Scrapie-responsive gene.

The Journal of Biological Chemistry
Michel DronMichael G Tovey

Abstract

We have recently described a novel mRNA denominated ScRG-1, the level of which is increased in the brains of Scrapie-infected mice (Dandoy-Dron, F., Guillo, F., Benboudjema, L., Deslys, J.-P., Lasmézas, C., Dormont, D., Tovey, M. G., and Dron, M. (1998) J. Biol. Chem. 273, 7691-7697). The increase in ScRG-1 mRNA in the brain follows the accumulation of PrPSc, the proteinase K-resistant form of the prion protein (PrP), and precedes the widespread neuronal death that occurs in late stage disease. In the present study, we have isolated a cDNA encoding the human counterpart of ScRG-1. Comparison of the human and mouse transcripts firmly established that both sequences encode a highly conserved protein of 98 amino acids that contains a signal peptide, suggesting that the protein may be secreted. Examination of the distribution of human ScRG-1 mRNA in adult and fetal tissues revealed that the gene was expressed primarily in the central nervous system as a 0.7-kilobase message and was under strict developmental control.

References

Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J Duguid, C Trzepacz
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Citations

Mar 17, 2000·Brain Research. Molecular Brain Research·F Dandoy-DronM Dron
Nov 12, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shu-Xun LiuBo-Lin Zhang
Dec 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Irina MilisavSamo Ribarič
Jul 21, 2005·The European Journal of Neuroscience·Michel DronFrançoise Dandoy-Dron
Nov 19, 2003·The European Journal of Neuroscience·Françoise Dandoy-DronMichel Dron
Sep 6, 2015·BMC Genomics·Allen HerbstJudd M Aiken
Mar 7, 2020·American Journal of Medical Genetics. Part a·Ana S A CohenRam Singh
Apr 17, 2020·Learning & Memory·Michaelina N NarteyJohn H McLean
Sep 29, 2020·Frontiers in Bioengineering and Biotechnology·Óscar López-PérezInmaculada Martín-Burriel

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