Characterization of the human gene coding for the swelling-dependent chloride channel ICln at position 11q13.5-14.1 (CLNS1A) and further characterization of the chromosome 6 (CLNS1B) localization

Gene
U O NaglM Paulmichl

Abstract

Expression cloning revealed a chloride channel (ICln) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human ICln-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A.

References

Mar 19, 1992·Nature·M PaulmichlD Clapham
Aug 1, 1995·Pflügers Archiv : European journal of physiology·M GschwentnerM Paulmichl
Jan 1, 1994·Genetic Analysis, Techniques and Applications·F FrancisH Lehrach
Jun 15, 1996·Nucleic Acids Research·K Hagiwara, C C Harris

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Citations

Apr 13, 2000·Brain Research. Brain Research Reviews·A Verkhratsky, C Steinhäuser
Nov 20, 2002·American Journal of Medical Genetics·Dongsheng BaiAntonio V Delgado-Escueta
May 24, 2000·The Journal of Biological Chemistry·E ScandellaM Paulmichl

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