PMID: 9161686Mar 1, 1997Paper

Characterization of the human thymic microenvironment: lymphoepithelial interaction in normal thymus and thymoma

Archives of Histology and Cytology
H K Müller-HermelinkA Marx

Abstract

Recent advances in tissue culture technology and molecular biology have extended our understanding of the functional morphology of the thymus. The importance of a crosstalk between lymphoid cells and stroma has been appreciated as a prerequisite for the normal development of both. The network of direct cellular interactions and soluble factors comprising part of the microenvironment is far from being elucidated but the highly ordered thymic architecture clearly plays a pivotal role in normal thymic function. Insight into the genetic control of stroma development is only emerging while knowledge on the genetic control of the various steps in T cell development is already advanced and rapidly expanding. The present paper gives an overview on the cellular components and matrix molecules of the human thymic microenvironment and their development during ontogeny. The intrathymic cytokine network is shortly reviewed. Special emphasis is put on molecules mediating lymphoepithelial interactions that are necessary for the expansion and early selection of immature thymocytes from precursor cells and for the generation of an MHC restricted and self tolerant T cell repertoire by positive and negative selection. Considering these physiologi...Continue Reading

Citations

Apr 11, 2008·General Thoracic and Cardiovascular Surgery·Meinoshin OkumuraYoshiki Sawa
May 29, 2012·Current Oncology Reports·Mark MikhailTarek Mekhail
Dec 5, 1998·Seminars in Oncology Nursing·M L Workman
Nov 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Øystein WendelboØystein Bruserud
Sep 14, 1999·Pathology, Research and Practice·S GattenlöhnerA Marx
Oct 9, 2002·The American Journal of Pathology·Masayoshi InouePetr Starostik
Nov 1, 2003·Annals of the New York Academy of Sciences·Alexander MarxPhilipp Ströbel
Jul 24, 2008·Journal of Cutaneous Pathology·Georgia LevidouAthina Androulaki
Dec 12, 2001·The Journal of Surgical Research·M OkumuraH Matsuda
Mar 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Shingo IchimiyaNoriyuki Sato
May 3, 2000·Histopathology·H K Müller-Hermelink, A Marx
Jun 26, 1999·Histopathology·S YonedaH K Müller-Hermelink
Apr 17, 1999·Nature·J FrankA M Christiano
Sep 12, 2000·Applied Immunohistochemistry & Molecular Morphology : AIMM·M W DattaD M Dorfman
Aug 21, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Yvonne M WikanderNora L Springer
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Diego FeroneLeo J Hofland
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C R ThomasP J Loehrer
Sep 7, 2000·Current Opinion in Oncology·H K Müller-Hermelink, A Marx
May 3, 2003·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·F Figen KaymazEsin Aşan

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