Characterization of the hypothermic component of LPS-induced dual thermoregulatory response in rats

Pharmacology, Biochemistry, and Behavior
M Devrim DoganEyup S Akarsu

Abstract

We have previously shown that Escherichia coli O111:B4 serotype lipopolysaccharide (LPS) produced a dual change in rectal temperature (Tb), in which hypothermia preceded fever at subthermoneutral ambient temperature (Tamb; 24-26 degrees C) in rats. In this study, the characteristics of the initial hypothermic response were evaluated. Hypothermia was significant when LPS (50 microg/kg, i.p.) was injected at thermoneutral Tamb (30 degrees C). There was no heat loss through tail skin during hypothermia. The open field activity of the rats did not change during this period. However, serum levels of tumor necrosis factor-alpha (TNF-alpha) elevated at the beginning of the hypothermia, whereas serum levels of interleukin (IL)-1beta and interferon (IFN)-gamma remained unchanged. A nonselective cyclooxygenase inhibitor (indomethacin, 5 mg/kg, s.c.) inhibited hypothermia and serum TNF-alpha elevation, which resulted in an acceleration of the subsequent pyrogenic response. Moreover, a nonselective inhibitor of nitric oxide synthase (nitro L-arginine methyl ester (L-NAME), 10 mg/kg, s.c.) not only abolished fever but also prolonged the initial hypothermic response. These data suggest that the hypothermic component of low dose LPS-induced d...Continue Reading

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Citations

Feb 7, 2003·Fundamental & Clinical Pharmacology·Muberra Devrim DoganEyup S Akarsu
Dec 26, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Katherine M NautiyalRae Silver
Mar 23, 2010·Brain, Behavior, and Immunity·Jason R Yee, Brian J Prendergast
May 16, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rovana Paludo ToyamaMaria Marlene de Souza Pires
Aug 2, 2005·Journal of Neuroscience Methods·Jorgete TomazettiCarlos Fernando Mello
Apr 30, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ana C Ribeiro, Levente Kapás
Jul 22, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tracey J WeilandStephen Kent
Jan 23, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Cihangir AkyolM Ayhan Kuzu
Feb 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eyup S Akarsu, Soner Mamuk

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