Jan 1, 1985

Characterization of the IgG antibody response to timothy grass pollen antigens

International Archives of Allergy and Applied Immunology
A MalleyK J Turner


The IgG and IgE antibody responses against timothy grass pollen antigen B (AgB) in several mouse strains were determined. Considerable variability in both responses was demonstrated, and (CBA/J X C57BL/6)F1 mice were selected for use in subsequent experiments. Anti-idiotypic-antibody-induced T suppressor cells almost completely suppressed AgB-specific IgE, but the IgG response was not altered. Further studies with photooxidized AgB (Ox-AgB) indicated that the IgG response was directed against an antigenic determinant expressed on both native antigen and Ox-AgB. Our data indicates that AgB possesses two distinct antigenic determinants, one that induces an IgE response, and one that induces an IgG response.

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Mentioned in this Paper

Mice, Inbred CBA
Timothy grass pollen
Mice, Inbred BALB C
C57BL/6 Mouse
Antigenic Specificity
CBA/J Mouse
Antibody Formation
Mice, Inbred C3H
Immunoglobulin E

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