Characterization of the immune cell infiltration landscape in bladder cancer to aid immunotherapy.

Archives of Biochemistry and Biophysics
Shanping ShiYang Xi

Abstract

The tumor microenvironment (TME) is composed mainly of tumor cells, tumorinfiltrating immune cells, and matrix components. Recent clinical studies have indicated that tumor immune cell infiltration (ICI) is related to the sensitivity of immunotherapy and the prognosis of patients with bladder cancer (BC). Nevertheless, up to now, the landscape of immune infiltration in BC has not been clearly defined. Here we present two algorithms to reveal the landscape of ICI in 277 cases of BC. Two kinds of ICI patterns were established, and ICI scores were based on the analysis of the main components. In sub-types with high ICI scores, we found highly expressed immunecheckpoint and activated transforming growth factor b and WNT signal pathways. These might be the cause of poor prognosis. A low ICI score indicated a better prognosis. Our study showed that ICI scores in immunotherapy could be a valid biomarker for the prognosis of patients and a predictive indicator. The evaluation of ICI patterns of a larger cohort of samples would expand our cognition of TME, and the present study might guide the strategies of immunotherapy for patients with BC.

References

Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert L CampDavid L Rimm
Feb 3, 2005·Nature Immunology·Hans Christian ProbstMaries van den Broek
Feb 16, 2006·Journal of the National Cancer Institute·Christos SotiriouMauro Delorenzi
Apr 25, 2006·Biostatistics·W Evan JohnsonAriel Rabinovic
Sep 22, 2010·Nature Immunology·Subhra K Biswas, Alberto Mantovani
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Aug 9, 2012·Theory in Biosciences = Theorie in Den Biowissenschaften·Günter P WagnerVincent J Lynch
Oct 12, 2013·Nature Communications·Kosuke YoshiharaRoel G W Verhaak
Apr 22, 2014·Urologic Oncology·Sean C Skeldon, S Larry Goldenberg
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael A PostowJedd D Wolchok
Mar 31, 2015·Nature Methods·Aaron M NewmanAsh A Alizadeh
Jul 17, 2015·Current Molecular Pharmacology·Monali VasekarMonika Joshi
Oct 2, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maurizio CallariGiampaolo Bianchini
Jan 20, 2017·Nature·Daniel S Chen, Ira Mellman
May 13, 2017·Cell Reports·Jesper Bertram BramsenClaus Lindbjerg Andersen
Jun 27, 2017·The Journal of Clinical Investigation·Mark AyersTerrill K McClanahan
Dec 21, 2017·The New England Journal of Medicine·Mark YarchoanElizabeth M Jaffee
Jan 26, 2018·Cancer Chemotherapy and Pharmacology·Sabeeh-Ur-Rehman Butt, Laeeq Malik
Feb 7, 2018·Cancer Treatment Reviews·Francesco MassariAndrea Ardizzoni
Sep 1, 2018·Cancer Treatment and Research·Anirban P Mitra, Siamak Daneshmand
Oct 13, 2018·Science·Razvan CristescuDavid Kaufman
Oct 21, 2018·Genome Research·Anand MayakondaH Phillip Koeffler
Dec 31, 2018·Journal of Experimental & Clinical Cancer Research : CR·Yin HeXiaosheng Wang
Apr 17, 2019·Cancer Immunology Research·Carolin PfannstielUNKNOWN BRIDGE Consortium, Germany
Mar 29, 2020·International Journal of Medical Sciences·Zonglong WuBenkang Shi
Nov 18, 2020·JAMA : the Journal of the American Medical Association·Andrew T LenisM D Mshs
Jan 7, 2021·Cancers·Antonio Lopez-BeltranRodolfo Montironi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.