Characterization of the Influence of Semen-Derived Enhancer of Virus Infection on the Interaction of HIV-1 with Female Reproductive Tract Tissues

Journal of Virology
Shannon A AllenThomas J Hope

Abstract

The majority of human immunodeficiency virus type 1 (HIV-1) transmission events occur in women when semen harboring infectious virus is deposited onto the mucosal barriers of the vaginal, ectocervical, and endocervical epithelia. Seminal factors such as semen-derived enhancer of virus infection (SEVI) fibrils were previously shown to greatly enhance the infectivity of HIV-1 in cell culture systems. However, when SEVI is intravaginally applied to living animals, there is no effect on vaginal transmission. To define how SEVI might function in the context of sexual transmission, we applied HIV-1 and SEVI to intact human and rhesus macaque reproductive tract tissues to determine how it influences virus interactions with these barriers. We show that SEVI binds HIV-1 and sequesters most virions to the luminal surface of the stratified squamous epithelium, significantly reducing the number of virions that penetrated the tissue. In the simple columnar epithelium, SEVI was no longer fibrillar in structure and was detached from virions but allowed significantly deeper epithelial virus penetration. These observations reveal that the action of SEVI in intact tissues is very different in the anatomical context of sexual transmission and beg...Continue Reading

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Citations

Jun 19, 2015·AIDS Research and Human Retroviruses·Marina R AlexanderPer Johan Klasse
May 7, 2016·Journal of Internal Medicine·P BergmanJ Münch
Jun 7, 2018·Chemical Communications : Chem Comm·Annika RöckerJan Münch
Mar 23, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Run-Hong ZhouJie-Liang Li
Feb 8, 2020·Physiological Reviews·Anna Le TortorecNathalie Dejucq-Rainsford
Mar 10, 2017·PloS One·James M MullinLuis J Montaner
Mar 25, 2017·Retrovirology·Samuel Mundia KariukiJeffrey R Dorfman
Jun 30, 2019·Virus Evolution·Rafael Sanjuán, María-Isabel Thoulouze
Jan 19, 2018·AIDS Research and Human Retroviruses·Kattayoun KordyPeter A Anton
Dec 17, 2020·International Journal of Molecular Sciences·Ignacio Relaño-Rodríguez, Maria Ángeles Muñoz-Fernández
Jan 1, 2019·Current Immunology Reviews·Kattayoun KordyGrace M Aldrovandi
Mar 16, 2021·Current HIV/AIDS Reports·Marta Rodriguez-GarciaMimi Ghosh
Aug 16, 2017·Accounts of Chemical Research·Daniel A SheikJerry Yang

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