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Characterization of the inhibition of glutathione reductase and the recovery of enzyme activity in exponentially growing murine leukemia (L1210) cells treated with 1,3-bis(2-chloroethyl)-1-nitrosourea

Biochemical Pharmacology

Sep 1, 1988

Meytal Cohen, D L Duvel

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Abstract

The inactivation of the enzyme glutathione reductase by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) was studied in exponentially growing murine leukemia cells. A 1-hr incubation with 1.6 +/- 0.2 microM BCNU resulted in a 50% inhibition of glutathione reductase, while 10 microM BCNU caus...read more

Mentioned in this Paper

Glutathione Reductase
Dose-Response Relationship, Drug
Metazoa
Leukemia
BiCNU
Leukemia L1210
Cell Survival
In Vitro [Publication Type]
Mouse, Swiss
Cell Division Phases
Paper Details
References
  • References1
  • Citations15
12

Characterization of the inhibition of glutathione reductase and the recovery of enzyme activity in exponentially growing murine leukemia (L1210) cells treated with 1,3-bis(2-chloroethyl)-1-nitrosourea

Biochemical Pharmacology

Sep 1, 1988

Meytal Cohen, D L Duvel

PMID: 3401259

DOI: 10.1016/0006-2952(88)90645-4

Abstract

The inactivation of the enzyme glutathione reductase by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) was studied in exponentially growing murine leukemia cells. A 1-hr incubation with 1.6 +/- 0.2 microM BCNU resulted in a 50% inhibition of glutathione reductase, while 10 microM BCNU caus...read more

Mentioned in this Paper

Glutathione Reductase
Dose-Response Relationship, Drug
Metazoa
Leukemia
BiCNU

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Paper Details
References
  • References1
  • Citations15
12

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