PMID: 8582132Nov 1, 1995Paper

Characterization of the insulin-antagonistic effect of growth hormone in insulin-dependent diabetes mellitus

Diabetic Medicine : a Journal of the British Diabetic Association
J FowelinI Lager

Abstract

To characterize its insulin-antagonistic effect, growth hormone (GH) was infused at variable rates (24, 12 or 6 mU kg-1 min-1) for 1 h in 7 IDDM patients. Saline infusion was used as control (C) and all patients participated in all studies. The effect of insulin was measured with the euglycaemic clamp technique for 6 h combined with d-(3-3H)-glucose to evaluate glucose turnover. The insulin levels during the clamps were similar in all studies (23 +/- 3 mU l-1). The infusions produced peak GH levels of (24 rate = 24) 157 +/- 11, (12 rate = 12) 76 +/- 7, and (6 rate = 6) 45 +/- 8 mU l-1 (mean +/- SEM). The insulin-antagonistic effect of GH on glucose uptake was seen after 2 h and was at a maximum 4 to 5 h after the start of the GH infusion (difference in glucose infusion rate between C and 24 was 1.7 +/- 0.4 mg kg-1 min-1, p < 0.01). The resistance was due to a less pronounced effect of insulin to both inhibit rate of appearance and to stimulate rate of disappearance. Infusion of GH at 12 mU kg-1 min-1 induced a less pronounced insulin resistance both with regards to maximal effect (glucose infusion rate C - GH 1.4 +/- 0.5 mg kg-1 min-1, p < 0.05) and duration (3 h). At 6 mU kg-1 min-1, a clear GH-induced insulin-antagonistic eff...Continue Reading

References

Aug 1, 1991·Metabolism: Clinical and Experimental·J Dietz, J Schwartz
Feb 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·J FowelinI Lager
Aug 1, 1989·The Journal of Clinical Endocrinology and Metabolism·C M AsplinW S Evans
Mar 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·S Laurell, G Tibbling
Nov 1, 1982·The Journal of Clinical Endocrinology and Metabolism·P R Bratusch-MarrainR A DeFronzo
May 1, 1980·Diabetes·J T HayfordR G Thompson
May 1, 1982·The Journal of Clinical Endocrinology and Metabolism·R G RosenfeldR L Hintz

❮ Previous
Next ❯

Citations

May 19, 2011·Analytical and Bioanalytical Chemistry·Richard I G Holt
Jan 10, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·R I G HoltP H Sönksen
Feb 20, 2016·Scientific Reports·Arkadiusz D LiśkiewiczHalina Jędrzejowska-Szypułka
Apr 1, 2008·British Journal of Pharmacology·R I G Holt, P H Sönksen
Mar 22, 2014·Scandinavian Journal of Medicine & Science in Sports·D TurnerR M Bracken
Feb 11, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·T JohansenK Malmlöf
Apr 29, 2015·Scandinavian Journal of Medicine & Science in Sports·D TurnerR M Bracken
Apr 1, 2010·Drug Testing and Analysis·Richard I G Holt
Mar 20, 2018·JFMS Open Reports·Maya Laura KönigCristina Pérez Vera

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
Matthew Pinsent
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Tammy L McNab, Hasnain M Khandwala
© 2021 Meta ULC. All rights reserved