Characterization of the intestinal absorption of seven flavonoids from the flowers of Trollius chinensis using the Caco-2 cell monolayer model

PloS One
Li-Jia LiuChen Liu

Abstract

The human Caco-2 cell monolayer model was used to investigate the absorption property, mechanism, and structure-property relationship of seven representative flavonoids, namely, orientin, vitexin, 2"-O-β-L-galactopyranosylorientin, 2"-O-β-L-galactopyranosylvitexin, isoswertisin, isoswertiajaponin, and 2"-O-(2"'-methylbutanoyl)isoswertisin from the flowers of Trollius chinensis. The results showed that these flavonoids were hardly transported through the Caco-2 cell monolayer. The compounds with 7-OCH3 including isoswertisin, isoswertiajaponin and 2"-O-(2"'-methylbutanoyl)isoswertisin were absorbed in a passive diffusion manner, and their absorbability was increased in the same order as their polarity. The absorption of the remaining compounds with 7-OH including orientin, vitexin, 2"-O-β-L-galactopyranosylorientin, and 2"-O-β-L-galactopyranosylvitexin involved transporter mediated efflux in addition to passive diffusion. Among the four compounds with 7-OH, those with a free hydroxyl group at C-2" such as orientin and vitexin were the substrates of P-glycoprotein (P-gp) and that with a free hydroxyl group at C-2' such as 2"-O-β-L-galactopyranosylorientin was the substrate of multidrug resistance protein 2 (MRP2). The results of ...Continue Reading

References

Oct 24, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·I C van der SandtD D Breimer
Feb 19, 2002·Journal of Ethnopharmacology·Yao Lan LiPaul Pui-Hay But
Mar 11, 2004·Journal of Asian Natural Products Research·Ru-Feng WangJong-Hee Park
Dec 29, 2006·Chemistry & Biodiversity·Shao-Qing CaiYukihiro Shoyama
Dec 24, 2013·Chinese Journal of Natural Medicines·Ming YuanXiu-Wei Yang

❮ Previous
Next ❯

Citations

Oct 27, 2015·Future Medicinal Chemistry·Elisabeta BaiceanuPierre Falson
Oct 16, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Xin MaoLan-Zhen Zhang
Feb 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zongxi SunShouying Du
May 6, 2019·International Journal of Molecular Sciences·Noelia Sánchez-MarzoEnrique Barrajón-Catalán

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

Waters Breeze
ChemOffice
SPSS

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.