Characterization of the intragenomic spread of the human endogenous retrovirus family HERV-W

Molecular Biology and Evolution
Javier Costas

Abstract

This study examines the intragenomic spread of the human endogenous retrovirus family HERV-W from insertions present within the draft sequence of the human genome. Identification of shared diagnostic differences and phylogenetic analyses revealed the existence of three main subfamilies. The average divergence between sequences for each of the subfamilies suggests that most of the HERV-W elements were inserted within the genome during a short period of evolutionary time. Each one of the subfamilies consists of two types of insertions, the expected proviral sequences and other sequences resembling the structure of processed retrogenes. These HERV-W retrosequences extend from the R region of the 5' long-terminal repeat (LTR) to the R region of the 3' LTR (as viral genomic RNAs), end in poly(A) 3' tails, and are flanked by direct repeats longer than the proviral integrations. Furthermore, several of the HERV-W retrosequences are 5'-truncated at different sites. I suggest the involvement of the L1 machinery in these integrations and discuss the characteristic features of the evolutionary history of HERV-W, with emphasis on the putative impact of HERV-W retrosequence integrations on the mammalian genome.

References

Sep 11, 1992·Trends in Genetics : TIG·P L DeiningerM H Edgell
Dec 30, 1991·Science·S L MathiasA Gabriel
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jun 1, 1988·Molecular and Cellular Biology·R Dornburg, H M Temin
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·S HaraguchiN K Day
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·R LöwerR Kurth
Aug 1, 1996·Immunological Reviews·K Nakagawa, L C Harrison
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·J Jurka
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·H PerronB Mandrand
Jul 1, 1997·The Journal of General Virology·P MedstrandJ Blomberg
May 20, 1998·Nature Genetics·H H Kazazian, J V Moran
Nov 13, 1998·Journal of Virology·P Medstrand, D L Mager
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M Mangeney, T Heidmann
Mar 5, 1999·Science·J V MoranH H Kazazian
Mar 11, 2000·Molecular Biology and Evolution·J Costas, H Naveira
Feb 29, 2000·Nature·J P Stoye, J M Coffin
Mar 31, 2000·Nature Genetics·C EsnaultT Heidmann
Apr 26, 2000·Genome Research·O K PickeralJ D Boeke
May 29, 2000·AIDS Research and Human Retroviruses·C VoissetG Paranhos-Baccala
Feb 7, 2001·Molecular and Cellular Biology·W WeiJ V Moran
Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·H KarlssonR H Yolken
Dec 26, 2001·Bioinformatics·S KumarM Nei

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Citations

Dec 31, 2005·Archives of Virology·J-M Yi, H-S Kim
Sep 8, 2007·Archives of Virology·J-W HuhH-S Kim
Nov 16, 2002·Current Opinion in Genetics & Development·Thomas H Eickbush, Anthony V Furano
Jun 30, 2009·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Juliette GimenezFrançois Mallet
Aug 14, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Gkikas MagiorkinisAris Katzourakis
May 14, 2005·Journal of Virology·Paula López-SánchezHoracio F Naveira
Mar 7, 2008·Microbiology and Molecular Biology Reviews : MMBR·Cécile VoissetDavid J Griffiths
Sep 24, 2005·Retrovirology·Bertrand BonnaudFrançois Mallet
Jul 11, 2006·Retrovirology·Christoffer NellåkerHåkan Karlsson
Jul 5, 2012·PloS One·Philippe PérotFrançois Mallet
Jan 30, 2007·PLoS Pathogens·Young Nam Lee, Paul D Bieniasz
Jul 31, 2007·Future Microbiology·Sunit Kumar Singh
Feb 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·François MalletBernard Mandrand
Jun 26, 2014·AIDS Research and Human Retroviruses·Jungwoo EoHeui-Soo Kim
Jan 29, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Fang Li, Håkan Karlsson
Jan 24, 2006·Experimental Cell Research·Magda MatouskováJirí Hejnar
Aug 11, 2010·Biochimica Et Biophysica Acta·Joseph M AntonyChristopher Power
Nov 13, 2012·PloS One·Darko GosencaWolfgang Seifarth
Aug 12, 2005·Cytogenetic and Genome Research·J Mayer, E Meese
May 26, 2006·Annual Review of Genomics and Human Genetics·Norbert Bannert, Reinhard Kurth
May 26, 2007·Trends in Genetics : TIG·David MoyesPatrick J Venables
Jan 1, 2006·Expert Review of Clinical Immunology·Antonina Dolei

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