Characterization of the larval olfactory response in Drosophila and its genetic basis

Behavior Genetics
P MonteJ R Carlson

Abstract

Drosophila larvae are attracted to a wide variety of chemical stimuli. The olfactory response to ethyl acetate, a powerful attractant, was found to be surprisingly well conserved across a variety of different wild-type strains. Strain differences are documented, however, both in attraction to ethyl acetate and in another chemosensory behavior: avoidance of an aversive stimulus. As a means of analyzing the extent of genetic heterogeneity within strains, one wild-type population, Canton-S, was screened for variant X chromosomes. An enrichment procedure was characterized and used to make the screening more efficient. Lines homozygous for individual X chromosomes were established, and all were found to exhibit a strong olfactory response, although evidence was found for variation among them. The olfactory response was found to be conserved through an extended period of larval development, including the final period during which larvae leave the culture medium in preparation for metamorphosis. The results are discussed in terms of the genetic basis of the response and the use of single-gene mutations as a means of dissecting olfactory system function.

References

Jan 1, 1987·Journal of Neurobiology·B A Chase, D R Kankel
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·W G QuinnS Benzer
Sep 1, 1984·Behavior Genetics·L Tompkins
Jan 1, 1980·Basic Life Sciences·V Rodrigues
Sep 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·S Benzer
Oct 5, 1979·Science·E O Aceves-Piña, W G Quinn

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Citations

Jan 1, 1996·Behavior Genetics·B Gordesky-GoldL Tompkins
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M McKennaJ Carlson
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S L Helfand, J R Carlson
Jun 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·R K Ayer, J Carlson
Oct 31, 2006·Chemical Senses·Bertram Gerber, Reinhard F Stocker
Feb 1, 2013·Chemical Senses·Sukant Khurana, Obaid Siddiqi
Jun 22, 2001·Proceedings. Biological Sciences·M Cobb, I Domain
May 18, 2007·Annual Review of Neuroscience·Leslie B Vosshall, Reinhard F Stocker
Jul 28, 2012·The Journal of Experimental Biology·Sara WassermanMark A Frye
May 27, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shelby A MontagueJohn R Carlson
May 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Dennis MathewJohn R Carlson
Dec 29, 2007·Journal of Neurogenetics·Craig WoodardJohn Carlson
Aug 1, 1990·Journal of Neurogenetics·C AyyubO Siddiqi
Feb 1, 1992·Journal of Neurogenetics·C WoodardJ Carlson
Jul 12, 2005·Current Opinion in Neurobiology·Anupama DahanukarJohn R Carlson
Dec 25, 2007·Nature Neuroscience·Matthieu LouisLeslie B Vosshall
Aug 12, 2000·Journal of Neurogenetics·M S Wuttke, L Tompkins
Jan 10, 2019·Frontiers in Behavioral Neuroscience·David A ClarkDennis Mathew
Jul 26, 2017·Scientific Reports·Tiffany BaiocchiAdler R Dillman
Oct 9, 2008·Sensors·Hyoung-Gon SongCheil Moon
Jul 1, 2006·The Journal of Experimental Biology·Cécile FaucherMarien de Bruyne
May 1, 1996·Trends in Genetics : TIG·J R Carlson
Dec 1, 1991·Trends in Neurosciences·J Carlson
May 11, 2005·Neuron·Scott A KreherJohn R Carlson

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