Characterization of the lung microbiome and exploration of potential bacterial biomarkers for lung cancer

Translational Lung Cancer Research
Chen ChengBing Gu

Abstract

Emerging evidence has suggested that dysbiosis of the lung microbiota may be associated with the development of lung diseases. However, the interplay between the lung microbiome and lung cancer remains unclear. The aim of the present study was to evaluate and compare differences in taxonomic and derived functional profiles in the lung microbiota between lung cancer and benign pulmonary diseases. Bronchoalveolar lavage fluid (BALF) samples were collected from 32 patients with lung cancer and 22 patients with benign pulmonary diseases, and further analyzed by 16S rRNA amplicon sequencing. The obtained sequence data were deeply analyzed by bioinformatics methods. A significant differentiation trend was observed between the lung cancer and control groups based on principal coordinate analysis (PCoA), while richness and evenness in the lung microbiome of lung cancer patients generally resembled those of patients with benign pulmonary diseases. Phylum TM7 and six genera (c:TM7-3, Capnocytophaga, Sediminibacterium, Gemmiger, Blautia and Oscillospira) were enriched in the lung cancer group compared with the control group (adjust P<0.05). The area under the curve (AUC) combining the microbiome with clinical tumor markers to predict lung...Continue Reading

Citations

Mar 7, 2021·Diagnostics·Qixin LengFeng Jiang
Apr 4, 2021·International Journal of Environmental Research and Public Health·Ersilia NigroAurora Daniele
Jun 14, 2021·Seminars in Cancer Biology·Muhammad Jameel Mughal, Hang Fai Kwok

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