PMID: 6978764Jun 1, 1982Paper

Characterization of the lymphokine responsible for migration-inhibitory activity against tumor cells

Cancer Research
M C Cohen

Abstract

Lymphokine-containing supernatants have the ability to inhibit the migration of a variety of tumor cells in vitro in the absence of cytotoxic effects. In the present study, this tumor migration inhibition activity has been characterized in order to determine whether the responsible factor is the same or different from other known migration-inhibitory lymphokines. Since no preparations purified to homogeneity are generally available for these various factors, a variety of indirect procedures is necessary to make this determination. The profile of effects of monosaccharides, protease inhibitors, and neuraminidase on tumor migration inhibition factor, taken in conjunction with previously reported studies of other physicochemical and biological properties, provides evidence that tumor migration inhibition factor is distinct from both migration inhibition and leukocyte-inhibitory factor. A lymphokine with migration-inhibitory activity against tumor cells is a good candidate for a variety of protective functions in vivo.

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
T BabaS Cohen
Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology
H ArvilommiE Karhumäki
© 2021 Meta ULC. All rights reserved