Characterization of the mechanical properties of bovine cortical bone treated with a novel tissue sterilization process

Cell and Tissue Banking
Nathan KemperRonald R Cobb

Abstract

Over the past decade chemical processing and engineering of musculoskeletal tissue (tendon and bone) has improved dramatically. The use of bone allograft and xenograft in reconstructive orthopedic and maxillofacial surgeries is increasing, yet severe complications can occur if the material is contaminated in any way. A novel tissue sterilization process, BioCleanse®, has been developed to clean and sterilize musculoskeletal tissue for implantation. The present study was designed to determine the effect of this novel cleaning process on the biomechanical properties of bovine cortical bone prior to implantation. The mechanical properties of treated bovine bone material were compared to human samples with respect to failure under compression, shear and three-point bending. The data demonstrate that bovine bone treated with the novel sterilization procedure has favorable biomechanical properties compared to that of human bone treated in a similar fashion.

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Citations

Nov 4, 2015·Regulatory Toxicology and Pharmacology : RTP·Kwang-il LeeJu-woong Jang
Mar 22, 2013·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Carolyne I AlbertGerald Harris
Aug 25, 2019·Marine Drugs·Patricia Diaz-RodriguezMariana Landín

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