Characterization of the metabolic phenotype of chronically activated lymphocytes

Lupus
Daniel R WahlAnthony W Opipari

Abstract

Activated lymphocytes proliferate, secrete cytokines, and can make antibodies. Normally activated B and T cells meet the bioenergetic demand for these processes by up-regulating aerobic glycolysis. In contrast, several lines of evidence suggest that pathogenic lymphocytes in autoimmune diseases like lupus meet ATP demands through oxidative phosphorylation. Using (13)C-glucose as a stable tracer, we found that splenocytes from mice with lupus derive the same fraction of lactate from glucose as control animals, suggesting comparable levels of glycolysis and non-oxidative ATP production. However, lupus splenocytes increase glucose oxidation by 40% over healthy control animals. The ratio between pentose phosphate cycle (PPC) activity and glycolysis is the same for each group, indicating that increased glucose oxidation is due to increased activity of the TCA cycle in lupus splenocytes. Repetitive stimulation of cultured human T cells was used to model chronic lymphocyte activation, a phenotype associated with lupus. Chronically activated T cells rely primarily on oxidative metabolism for ATP synthesis suggesting that chronic antigen stimulation may be the basis for the metabolic findings observed in lupus mice. Identification of di...Continue Reading

References

Oct 1, 1992·Bioscience Reports·F ButtgereitM Müller
Feb 1, 1992·Biological Mass Spectrometry·W N LeeZ K Guo
Nov 15, 1983·The Biochemical Journal·E BaumgartenT Pozzan
Aug 1, 1996·The Journal of Clinical Investigation·M KoshyM K Crow
Sep 1, 1996·Journal of Applied Physiology·J F GautierP J Lefèbvre
Apr 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K A Brand, U Hermfisse
Feb 26, 1998·Immunological Reviews·G PawelecM Adibzadeh
Mar 13, 1998·Scandinavian Journal of Immunology·Y L YeB L Chiang
Feb 25, 2000·Biochemical Pharmacology·F ButtgereitM D Brand
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·C BeetonE Béraud
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathryn E FouldsHao Shen
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hidefumi KojimaMichail V Sitkovsky
Mar 22, 2002·Nature Reviews. Immunology·M J ShlomchikM J Mamula
Jul 18, 2002·Immunity·Kenneth A FrauwirthCraig B Thompson
Nov 7, 2002·Journal of Autoimmunity·Joseph M TuscanoM Eric Gershwin
Mar 13, 2003·Arthritis and Rheumatism·Jeffrey J BednarskiGary D Glick
Jun 5, 2003·The Journal of Clinical Investigation·Heike WulffK George Chandy
Aug 28, 2003·Nature Immunology·Robert A Seder, Rafi Ahmed
Dec 4, 2003·Nature Reviews. Immunology·Oreste Acuto, Frédérique Michel
Jun 19, 2004·International Reviews of Immunology·Andras PerlKatalin Banki
Jun 23, 2004·Trends in Immunology·Andras PerlKatalin Banki
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gyorgy NagyAndras Perl
Nov 13, 2004·Arthritis Research & Therapy·Carol A Hitchon, Hani S El-Gabalawy
May 27, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fawzi BoumezbeurVincent Lebon
Jul 12, 2005·Oncogene·Daniel E BauerCraig B Thompson
Oct 18, 2005·Molecular and Cellular Biology·Richard V ParryJames L Riley
Oct 22, 2005·Nature Reviews. Immunology·Casey J FoxCraig B Thompson

❮ Previous
Next ❯

Citations

Jan 10, 2013·Annual Review of Immunology·Nancie J MacIverJeffrey C Rathmell
Oct 17, 2013·Autoimmunity·Zachary Oaks, Andras Perl
Apr 19, 2015·Arthritis Research & Therapy·Zhen YangCornelia M Weyand
Feb 22, 2012·Trends in Immunology·Valerie A Gerriets, Jeffrey C Rathmell
Mar 8, 2016·The Journal of Clinical Investigation·Hung D NguyenXue-Zhong Yu
Aug 15, 2012·Immunological Reviews·Ruoning Wang, Douglas R Green
Aug 15, 2012·Immunological Reviews·Adam T Waickman, Jonathan D Powell
Mar 19, 2015·Immunity·Samuel E WeinbergNavdeep S Chandel
Sep 23, 2011·Biochemical Society Transactions·Helen R GriffithsGeorge D Kitas
Feb 24, 2015·Journal of Biotechnology·Lidia De RiccardisMichele Maffia
Jan 8, 2015·Frontiers in Immunology·Craig Alan Byersdorfer
Jul 5, 2016·Biochimica Et Biophysica Acta·Kheshwant S GillPatrick F Forde
Oct 7, 2016·Current Rheumatology Reports·Seung-Chul ChoiLaurence Morel
Nov 25, 2016·European Journal of Immunology·Valentina PucinoClaudio Mauro
Feb 13, 2015·Science Translational Medicine·Yiming YinLaurence Morel
Apr 1, 2017·Nature Reviews. Rheumatology·Laurence Morel
Apr 7, 2017·Nature Reviews. Rheumatology·Jillian P RhoadsJeffrey C Rathmell
May 26, 2017·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Yusuke TakeshimaKazuhiko Yamamoto
Jun 24, 2017·Current Opinion in Rheumatology·Yaima L LightfootMariana J Kaplan
Feb 27, 2018·Frontiers in Immunology·Hung D NguyenXue-Zhong Yu
Jan 25, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ian A Bettencourt, Jonathan D Powell
Jan 14, 2012·Journal of Magnetic Resonance Imaging : JMRI·Aurélien MassireNicolas Boulant
Jun 12, 2019·Biotechnology and Bioengineering·Elena CostariolQasim A Rafiq
Jun 20, 2018·Frontiers in Immunology·Francesco UrsiniRoberto De Giorgio
Jun 6, 2018·Frontiers in Immunology·Yazan AlwarawrahNancie J MacIver
Jan 18, 2020·Nature Reviews. Rheumatology·Amir Sharabi, George C Tsokos
Nov 27, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yiming YinLaurence Morel
Jul 28, 2017·Frontiers in Cellular Neuroscience·Bryan LeawHenrik Hagberg
Jun 2, 2020·Immunometabolism·Bowen WuCornelia M Weyand
Jul 6, 2018·Cellular and Molecular Life Sciences : CMLS·Zijun WangQianjin Lu
Apr 8, 2020·Immunometabolism·Milena VukelicGeorge C Tsokos
Oct 6, 2020·Frontiers in Medicine·Eóin C O'BrienFionnuala B Hickey
Oct 3, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Daniel J PerryLaurence Morel
Aug 4, 2020·Journal of Translational Autoimmunity·Chen-Xing ZhangWei Zhou
May 31, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·M M Faas, P de Vos
Oct 27, 2020·Journal of Medicinal Chemistry·Yibin XuNouri Neamati

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.