Characterization of the mononuclear infiltrate in Bowen's disease (squamous cell carcinoma in situ). Evidence for a T cell-mediated anti-tumour immune response

Virchows Archiv. A, Pathological Anatomy and Histopathology
J M HabetsT van Joost

Abstract

We investigated the dermal inflammatory infiltrate and the expression of HLA-DR and beta 2-microglobulin on the tumour cells in 8 Bowen's disease (BD) using a series of monoclonal antibodies. The inflammatory infiltrate was classified as mild, moderate or heavy. The infiltrate in all cases consisted mainly of T cells (55 +/- 21%) and where the T helper (TH) subset predominated over the T suppressor/cytotoxic (TS/C) subset (TH/TS/C ratio of 2.4 +/- 1.0). The mean percentage of HLA-DR positive cells was 58 +/- 18%, Langerhans cells (LC) 4 +/- 1% and Leu-M5 positive cells (monocytes/macrophages) 9 +/- 2%. The mean percentage of B cells and natural killer (NK) cells was 4 +/- 5% and 1 +/- 2% respectively. B cells and NK cells did not invade any of the tumours. In the 5 BD with moderate or heavy infiltrate, TH cells, TS/C cells and Leu-M5 positive cells did invade the tumour. In the tumour area where there was invasion, the number of LC was increased and HLA-DR was expressed on the cells. beta 2-microglobulin was generally expressed on the tumour cells of BD. We concluded that there is evidence for a T cell-mediated anti-tumour immune response which may account for the infrequent invasive growth in BD.

References

Mar 1, 1979·Journal of the National Cancer Institute·R B Herberman, H T Holden
Apr 1, 1987·Journal of the American Academy of Dermatology·A KohchiyamaH Ueki
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·E RalfkiaerD Y Mason
Dec 1, 1985·International Journal of Dermatology·L A HuaR W Goltz
May 1, 1981·The British Journal of Dermatology·M L Turbitt, R M Mackie
Nov 1, 1982·The Journal of Dermatologic Surgery and Oncology·N F EaglsteinJ E Allen
Mar 1, 1984·The Journal of Investigative Dermatology·E B BröckerC Sorg
Oct 2, 1981·Science·R B Herberman, J R Ortaldo
May 1, 1985·Immunology Today·A Mantovani, R Evans

❮ Previous
Next ❯

Citations

Nov 7, 2000·Journal of Surgical Oncology·P G Jackson, S R Evans
Aug 1, 1996·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A Iamaroon, R A Vickers
Dec 18, 2004·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·George T LiuJohn S Steinberg
Feb 24, 2001·Journal of the American Academy of Dermatology·A Mackenzie-WoodM L Owens
Mar 21, 1998·European Journal of Clinical Investigation·C Cocito, H Maes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bowen's Disease

Bowen's disease is thought of as an easily-treatable early stage of skin cancer, characterized by red, scaly patches on the skin. Discover the latest research on Bowen's disease here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.