Characterization of the myelotoxicity of chloramphenicol succinate in the B6C3F1 mouse.

International Journal of Experimental Pathology
John TurtonC Michael Andrews

Abstract

Chloramphenicol (CAP) is haemotoxic in man, inducing two types of toxicity. First, a dose-related, reversible anaemia with reticulocytopenia, sometimes seen in conjunction with leucopenia and thrombocytopenia; this form of toxicity develops during drug treatment. The second haemotoxicity is aplastic anaemia (AA) which is evident in the blood as severe pancytopenia. AA development is not dose-related and occurs weeks or months after treatment. We wish, in the longer term, to investigate CAP-induced AA in the busulphan-pretreated mouse. However, as a prelude to that study, we wanted to characterize in detail the reversible haemotoxicity of CAP succinate (CAPS), administered at high dose levels in the mouse, and follow the recovery of the bone marrow in the post-dosing period. Female B6C3F1 mice were gavaged with CAPS at 0, 2500 and 3500 mg/kg, daily, for 5 days and sampled (n = 5) at 1, 7, 14 and 21 days post-dosing. Blood, bone marrow and spleen samples were analysed and clonogenic assays carried out. At day 1 post-dosing, at both CAPS dose levels, decreases were seen in erythrocytes and erythrocyte precursors; marrow erythroid cells were reduced. Reductions were also evident in splenic nucleated cell counts, blood high fluoresc...Continue Reading

References

Apr 1, 1976·British Journal of Haematology·A MorleyJ Remes
Nov 1, 1990·International Journal of Pediatric Otorhinolaryngology·B BurkeyJ Brunberg
Jan 1, 1990·American Journal of Clinical Pathology·A TichelliC Nissen
Nov 1, 1988·Journal of Clinical Pathology·S E Kinsey, M J Watts
Dec 1, 1974·The Australian Journal of Experimental Biology and Medical Science·A Morley, J Blake
Jun 1, 1974·British Journal of Haematology·K Ajlouni, T D Doeblin
Aug 1, 1970·Archives of Internal Medicine·A A YunisA Restrepo
Jun 16, 1969·JAMA : the Journal of the American Medical Association·R O WallersteinF R Morrison
Oct 27, 1983·The New England Journal of Medicine·G R Adams, H A Pearson
Jul 1, 1995·American Journal of Clinical Pathology·S A BentleyM E Brecher
Dec 1, 1994·International Journal of Oral and Maxillofacial Surgery·M Kunkel, W Hochban
Jul 1, 1994·Indian Journal of Pediatrics·K P KushwahaA K Rathi
Jun 15, 1993·American Journal of Ophthalmology·F T FraunfelderA A Yunis
May 8, 1997·The New England Journal of Medicine·N S Young, J Maciejewski
Apr 15, 1996·Physical Review. B, Condensed Matter·A Ait-Ouali, S Jandl
Oct 19, 1999·Human & Experimental Toxicology·J A TurtonT C Williams
Oct 20, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J A TurtonT C Williams
Apr 11, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M F FestingJ A Turton
Sep 7, 2001·Precambrian Research·A H Knoll
Jun 19, 2002·Veterinary Clinical Pathology·Kurt L ZimmermanEric Wright
Nov 7, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J A TurtonF M Gibson
Mar 19, 2003·International Journal of Experimental Pathology·J A TurtonT C Williams
Sep 1, 1958·The Journal of Clinical Investigation·D RUBINJ P STORAASLI
Jul 8, 1961·JAMA : the Journal of the American Medical Association·C M HUGULEYD E BERGSAGEL
Oct 13, 1960·The New England Journal of Medicine·L M ROSENBACHW J MITUS
Jun 3, 1965·The New England Journal of Medicine·J L SCOTTJ S LAWRENCE
Dec 1, 1954·American Journal of Physical Anthropology·R T SIMMONSN M SEMPLE
Jul 7, 1955·The New England Journal of Medicine·I H KRAKOFFJ H BURCHENAL
Dec 1, 1950·Annals of Internal Medicine·M L RICHR J HOFFMANN
Apr 29, 1950·Journal of the American Medical Association·I F VOLINIS O SCHWARTZ
Jan 1, 1991·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·K Wolff

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Citations

May 23, 2012·Antimicrobial Agents and Chemotherapy·Alison E BarnhillSteve A Carlson
Jun 20, 2007·The Veterinary Clinics of North America. Exotic Animal Practice·Christal Pollock
Jun 20, 2007·The Veterinary Clinics of North America. Exotic Animal Practice·Michelle G Hawkins, Jennifer E Graham
Nov 13, 2013·Seminars in Hematology·Phillip Scheinberg, Jichun Chen
Dec 17, 2014·Journal de mycologie médicale·M R P JosephM E Hamid
Jul 31, 2007·International Journal of Toxicology·Kang YuXin-Hua Liu

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