Characterization of the neuraminidase genes from human influenza A viruses circulating in Iran from 2010 to 2015

Archives of Virology
Elham MoasserHassan Zaraket

Abstract

Characterization of influenza viruses is critical for detection of new emerging variants. Herein, we analyzed the genetic diversity and drug susceptibility of the neuraminidase gene (NAs) expressed by influenza A/H1N1pdm09 and A/H3N2 viruses circulating in Iran from 2010 to 2015. We genetically analyzed the NAs of 38 influenza A/H1N1pdm09 and 35 A/H3N2 isolates. The Iranian A/H1N1pdm09 viruses belonged to seven genogroups/subgenogroups, with the dominant groups being genogroups 6B and 6C. The A/H3N2 isolates fell into six gneogroups/subgenogroups, with the dominant genogroups being 3C and 3C.2a. The most common mutations detected among the A/H1N1pdm09 viruses included N44S, V106I, N200S, and N248D. All H1N1pdm09 viruses were genetically susceptible to the NAIs. However, one A/H1N1pdm09 virus from the 2013-2014 season possessed an NA-S247N mutation, which reduces the susceptibility to oseltamivir. In case of H3N2, none of the analyzed Iranian strains carried a substitution that might affect its susceptibility to NAIs. The ongoing evolution of influenza viruses and the detect of influenza viruses with reduced susceptibility to NAIs warrants continuous monitoring of the circulating strains.

References

Feb 27, 2001·The Pediatric Infectious Disease Journal·R J WhitleyP Ward
Jul 5, 2006·Molecular Biology and Evolution·Yoshiyuki Suzuki
Mar 5, 2009·The New England Journal of Medicine·Anne Moscona
Dec 24, 2009·PLoS Currents·Martha NelsonKelly Henrickson
Dec 15, 2010·The Journal of Infectious Diseases·Tiffany G SheuLarisa V Gubareva
Jan 7, 2011·PloS One·Weifeng ShiDesmond G Higgins
Jul 13, 2011·Nature Reviews. Microbiology·Rafael A Medina, Adolfo García-Sastre
Dec 2, 2011·PloS One·Denis K ByarugabaFred Wabwire-Mangen
Mar 24, 2012·Current Opinion in Virology·Michael G Ison
May 9, 2012·The Journal of Infectious Diseases·Alicia M Fry, Larisa V Gubareva
Nov 3, 2012·Enfermedades infecciosas y microbiología clínica·Andrés AntónTomás Pumarola
Jan 4, 2013·Influenza and Other Respiratory Viruses·Jennifer L McKimm-Breschkin
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Nov 12, 2013·Molecular Biology and Evolution·Vanessa Garcia, Stéphane Aris-Brosou
Apr 5, 2014·Cellular and Molecular Life Sciences : CMLS·Arianna LoregianGiorgio Palù
Sep 24, 2014·Antimicrobial Agents and Chemotherapy·Alireza EshaghiJonathan B Gubbay
Oct 16, 2015·Jundishapur Journal of Microbiology·Nastaran KhodadadAmir Emami
Jan 31, 2017·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Neli KorsunJohn McCauley

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
glycosylation

Software Mentioned

GISAID
ClustalX
Molecular Evolutionary Genetic Analysis ( MEGA )

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.