Characterization of the Nutritional Composition of a Biotechnologically Produced Oyster Mushroom and its Physiological Effects in Obese Zucker Rats.

Molecular Nutrition & Food Research
Garima MaheshwariKlaus Eder

Abstract

Sustainable protein sources are needed to meet the increasing protein demands of a continuously growing world population. This study is focused on the biotechnological production of a protein rich oyster mushroom (Pleurotus sajor-caju; PSC) by valorization of an agricultural side stream and the evaluation of the physiological effects of PSC in a rat model of metabolic syndrome. PSC is produced via submerged cultivation in a 150 L bioreactor that utilizes isomaltulose molasses as its sole carbon source, and is further analyzed for its nutritional composition. A feeding trial is performed using Zucker rats which are fed a 5% PSC supplemented diet, for 4 weeks. Biochemical analyses reveal a significant reduction of the liver lipid concentrations and liver inflammation in the PSC fed obese rats in comparison to the obese rats from the control group. Hepatic qPCR analyses, differential transcript profiling, and enzyme activity measurements reveal a number of altered pathways that may be responsible for these anti-steatotic and anti-inflammatory effects of the mushroom. Bioconversion of a low quality agricultural side stream to an improved protein source is performed by submerged cultured PSC, and the obtained mycelium shows strong a...Continue Reading

References

Oct 1, 1978·Analytical Biochemistry·A Hara, N S Radin
Jan 1, 1975·Methods in Enzymology·C M NepokroeffJ W Porter
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H KellerW Wahli
Feb 15, 1997·European Journal of Biochemistry·J D McGarry, N F Brown
Apr 18, 1998·Gastroenterology·C P Day, O F James
Nov 4, 2000·Biochimica Et Biophysica Acta·A Cavaggioni, C Mucignat-Caretta
Dec 26, 2001·Nucleic Acids Research·Ron EdgarAlex E Lash
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Mar 21, 2003·Biochemical and Biophysical Research Communications·Irfan RahmanOkezie I Aruoma
Mar 16, 2006·Journal of Agricultural and Food Chemistry·Shu Hui HuJinn Chyi Wang
May 17, 2006·Perspectives in Biology and Medicine·Richard SullivanNeil J Rowan
Feb 2, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Sevki Adem, Mehmet Ciftci
May 15, 2008·Journal of Animal Physiology and Animal Nutrition·P NguyenH Dumon
Mar 5, 2009·The Journal of Biological Chemistry·Yingjiang ZhouLiangyou Rui
Jun 8, 2011·Trends in Endocrinology and Metabolism : TEM·Nicolas VenteclefEckardt Treuter
Jan 10, 2012·Nutrition Reviews·Barry M PopkinShu Wen Ng
Mar 8, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lefki-Maria PapaspyridiNikolas Fokialakis
May 2, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·D CompareG Nardone
Nov 7, 2012·Biochimica Et Biophysica Acta·Caroline RigaultJean Demarquoy
Oct 1, 2011·Saudi Journal of Biological Sciences·Nuhu AlamTae Soo Lee
Sep 1, 1996·World Journal of Microbiology & Biotechnology·S T Chang, J A Buswell
Apr 1, 2014·Food Chemistry·Ashagrie Z WoldegiorgisGregory R Ziegler
Apr 15, 2014·Applied Microbiology and Biotechnology·Wei-Hsuan Hsu, Tzu-Ming Pan
Sep 27, 2014·BMC Complementary and Alternative Medicine·Sook Shien LeeSzu Ting Ng
Feb 3, 2015·Journal of Lipid Research·Fei WangPatrick Tso
Aug 21, 2015·European Journal of Clinical Investigation·Scott M Grundy
Apr 8, 2016·Environmental Science & Technology·Ceren HiçJürgen P Kropp
Sep 7, 2016·Food Chemistry·Miriam SariReinhard Hambitzer

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Feb 10, 2021·Redox Biology·Irwin K Cheah, Barry Halliwell

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