PMID: 9168232May 20, 1997Paper

Characterization of the pathogenic KU-SHIV model of acquired immunodeficiency syndrome in macaques

AIDS Research and Human Retroviruses
S V JoagO Narayan

Abstract

By animal-to-animal passage in macaques we derived a pathogenic chimeric simian-human immunodeficiency virus (SHIV) that caused CD4+ T cell loss and AIDS in pigtail macaques and used it to inoculate 20 rhesus and pigtail macaques by the intravaginal and intravenous routes. On the basis of the outcome of infection and patterns of CD4+ T cell loss and viral load, disease was classified into four patterns: acute, subacute, chronic, and nonprogressive infection. During the study period, 15 of the 20 animals developed fatal disease, including AIDS, encephalitis, pneumonia, and severe anemia. Opportunistic pathogens identified in these animals included Pneumocystis, cytomegalovirus, Cryptosporidium, Toxoplasma, and Candida. No single parameter by itself predicted outcome, although a combination of low CD4+ T cell counts in blood, high plasma virus levels, and presence of autoantibodies to red blood cells reliably predicted a fatal outcome. Five animals (25%) died within 3 months of inoculation and constituted the group with acute disease, whereas the nine animals (45%) with subacute disease died between 3 and 8 months postinoculation. This 70% mortality within 8 months is significantly shorter than in HIV-1-infected human beings, of ...Continue Reading

References

Dec 14, 1989·The New England Journal of Medicine·D D HoM Alam
Nov 1, 1995·Journal of Virology·J T LiJ G Sodroski
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·P A LuciwC Cheng-Mayer
Apr 15, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·A MuñozJ P Phair
Jan 1, 1994·AIDS Research and Human Retroviruses·P U CameronR M Steinman
Feb 11, 1993·The New England Journal of Medicine·D D HoE S Daar
Mar 1, 1993·Microbiological Reviews·J A Levy
Mar 1, 1995·Journal of Neurovirology·G W ZhuE B Stephens

❮ Previous
Next ❯

Citations

Apr 1, 2000·Microbes and Infection·S V Joag
Sep 10, 2008·Journal of Neurovirology·Rachel WilliamsShilpa Buch
Aug 25, 2000·AIDS Research and Human Retroviruses·E B StephensV H Gattone
Apr 12, 2003·AIDS Research and Human Retroviruses·Zhihai SiJoseph Sodroski
Feb 12, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A de la Concha-BermejilloF W Bazer
Aug 26, 1998·AIDS Research and Human Retroviruses·L ForesmanS V Joag
Sep 25, 1998·Journal of Medical Primatology·S V JoagO Narayan
Sep 25, 1998·Journal of Medical Primatology·L E Kimball, M L Bosch
Dec 11, 1999·Journal of Medical Primatology·N L Haigwood
Nov 18, 2011·Journal of Virology·Nichole R KlattJason M Brenchley
Dec 8, 2004·Journal of Neuroimmunology·Shilpa BuchOpendra Narayan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.