Characterization of the Percutaneous Absorption of Ketoprofen Using the Franz Skin Finite Dose Model

Postgraduate Medicine
August S BassaniHa Phan

Abstract

Ketoprofen is an analgesic, anti-inflammatory agent commonly used in the management of chronic musculoskeletal pain. The aim of this study is to characterize the percutaneous absorption of 2 ketoprofen formulations (ketoprofen 10% in Pluronic Lecithin Organogel (PLO) and ketoprofen 10% in Lipoderm, referred to as phospholipid base), when applied to the human cadaver trunk skin, in vitro, using the Franz skin finite dose model. PLO and phospholipid base are vehicles used to facilitate the delivery of drugs into and through the skin following topical applications. The percutaneous absorption of ketoprofen was evaluated using human cadaver trunk skin from 3 donors. The skin was cut into small sections and cultured within Franz diffusion cells. A variable finite dose of each formulation was then applied to 3 replicate skin sections per donor and receptor solutions were collected at predetermined time points (0, 4, 8, 12, 24, 32, and 48 hr). After the last receptor sample was collected, skin surfaces were washed and split into epidermis and dermis. Collected samples were analyzed using HPLC. Both PLO and phospholipid base were capable of facilitating the absorption of ketoprofen across human cadaver trunk skin. However, ketoprofen, ...Continue Reading

References

Jul 12, 2003·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Christopher R CannavinoMark D Bracker
Jun 3, 2006·Clinical Rheumatology·Thomas J Schnitzer
Aug 27, 2009·Skin Pharmacology and Physiology·T J FranzS G Raney
Sep 8, 2010·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Bram BaertBart De Spiegeleer
Nov 19, 2011·Best Practice & Research. Clinical Rheumatology·Marco A CimminoMaurizio Cutolo
Feb 4, 2014·The Journal of the American Academy of Orthopaedic Surgeons·Richard L UhlAndrew H Dubin

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Citations

Jan 19, 2018·The American Journal of Hospice & Palliative Care·Bryce KayhartJonathan G Leung

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