PMID: 11923061Mar 30, 2002Paper

Characterization of the pharmacokinetics of buprenorphine and norbuprenorphine in rats after intravenous bolus administration of buprenorphine

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Sumithra GopalA Cowan

Abstract

The purpose of this project was to characterize the dose-dependent pharmacokinetics of buprenorphine (BN) and norbuprenorphine (NBN), the primary metabolite, after intravenous administration of different doses of BN to rats. Adult male Sprague-Dawley rats were divided into six groups and received a single intravenous bolus dose of 0.1, 0.3, 1, 3, 10 or 30 mg/kg of BN. A separate study was performed where BN and NBN were simultaneously administered intravenously (1 mg/kg+1 mg/kg). Plasma samples were obtained by centrifugation of the blood and analyzed for BN and NBN using a sensitive and selective gas chromatographic-mass spectrometric (GC-MS) bio-analytical method. Noncompartmental and compartmental methods were used to perform pharmacokinetic data analysis. BN declined triexponentially with a dose-dependent increase in its volume of distribution, V(ss) (8.37-18.2 l/kg) and clearance CL (2.70-6.10 l/h per kg). The pharmacokinetics of NBN were linear and biexponential. Coadministration of BN and NBN resulted in a significant increase in the volume of distribution and clearance of BN. The present results suggest that the nonlinear disposition in the clearance and volume of distribution of BN can be attributed, in part, to the in...Continue Reading

References

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Citations

Jan 11, 2007·Psychopharmacology·Adrie W BruijnzeelMark S Gold
Oct 20, 2012·Lab Animal·Michael GuarnieriPatricia Zadnik
Jun 4, 2008·American Journal of Veterinary Research·Ursula KrotscheckAmy A Little
Nov 16, 2010·The Veterinary Clinics of North America. Exotic Animal Practice·Butch Kukanich
Feb 24, 2006·European Journal of Pharmacology·Werner EnglbergerTieno Germann
May 27, 2005·Toxicology Letters·Bruno MegarbaneFrédéric J Baud
Mar 19, 2014·Drug and Alcohol Dependence·Samantha C LeeChristopher Welsh
Oct 27, 2016·The Journal of Pharmacy and Pharmacology·Anand JoshiPhillip M Gerk
May 27, 2004·Natural Product Reports·Kenneth W Bentley
Jan 1, 2003·Human & Experimental Toxicology·S W BorronF J Baud
Jun 17, 2011·The Clinical Journal of Pain·Howard S Smith
Feb 1, 2005·Drug Metabolism and Pharmacokinetics·Kiyoshi Yamaoka, Yoshinobu Takakura
Feb 2, 2013·The Journal of Pharmacology and Experimental Therapeutics·Lino BecerraDavid Borsook
Feb 7, 2007·The Journal of Pharmacology and Experimental Therapeutics·Ashraf YassenMeindert Danhof
Jan 18, 2017·Pharmacology Research & Perspectives·Nora M HagelbergTeijo I Saari
Dec 23, 2019·Journal of Pharmaceutical and Biomedical Analysis·Camille CohierOlivier Roussel
Dec 22, 2019·Drug and Alcohol Dependence·Lindsey R HammerslagMichael T Bardo
Mar 23, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sanelisiwe P XhakazaSooraj Baijnath

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