Characterization of the Phenomenon of rapid tolerance to ethanol

Alcohol
J M KhannaG Shah

Abstract

Motor impairment (tilt-plane) and hypothermia tests were used to further characterize the phenomenon of rapid tolerance to ethanol. Five experiments were carried out to clarify the relationship between rapid and chronic tolerance. The first experiment demonstrated that the extent of tolerance on day 2 produced by the single dose of 4 g/kg alcohol on day 1 was similar to that resulting from two divided doses, administered 2 h apart. In the second experiment, a linear relationship between treatment dose and rapid tolerance development was demonstrated in that higher day 1 treatment doses resulted in greater rapid tolerance development. In the third, a parallel dose-response relationship, similar to that known for chronic tolerance, was observed for rapid tolerance. In the fourth experiment, we compared the development of rapid tolerance under three different conditions: (a) in groups of rats that were not subjected to testing at all (no testing); on day 1, (b) in groups of rats that were not tested on the apparatus but handled at all test times on day 1 (dummy testing); and (c) in groups of rats that were tested at all test times on day 1 (testing or intoxicated group). No testing on day 1 failed to produce rapid tolerance to eth...Continue Reading

References

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Citations

Dec 18, 2002·Journal of Neurobiology·Fred W Wolf, Ulrike Heberlein
Dec 1, 2001·European Journal of Pharmacology·A D Barbosa, G S Morato
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·R L BellW J McBride
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May 17, 2008·Alcoholism, Clinical and Experimental Research·Melanie L SchwandtChristina S Barr
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Jan 18, 2008·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Adriana Dias Elpo Barbosa, Gina Struffaldi Morato
Jan 18, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Carolina L Haass-Koffler, Roberta Perciballi
Jan 24, 2017·Alcoholism, Clinical and Experimental Research·Tiffani D M Berkel, Subhash C Pandey

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