Characterization of the plant-specific BREVIS RADIX gene family reveals limited genetic redundancy despite high sequence conservation

Plant Physiology
Georgette C BriggsChristian S Hardtke

Abstract

To date, the function of most genes in the Arabidopsis (Arabidopsis thaliana) genome is unknown. Here we present the first analysis of the novel, plant-specific BRX (BREVIS RADIX) gene family. BRX has been identified as a modulator of root growth through a naturally occurring loss-of-function allele. The biochemical function of BRX is enigmatic, however several domains in BRX are conserved in the proteins encoded by the related BRX-like (BRXL) genes. The similarity between Arabidopsis BRXL proteins within these domains ranges from 84% to 93%. Nevertheless, analysis of brx brx-like multiple mutants indicates that functional redundancy of BRXLs is limited. This results mainly from differences in protein activity, as demonstrated by assaying the propensity of constitutively expressed BRXL cDNAs to rescue the brx phenotype. Among the genes tested, only BRXL1 can replace BRX in this assay. Nevertheless, BRXL1 does not act redundantly with BRX in vivo, presumably because it is expressed at a much lower level than BRX. BRX and BRXL1 similarity is most pronounced in a characteristic tandem repeat domain, which we named BRX domain. One copy of this domain is also present in the PRAF (PH, RCC1, and FYVE)-like family proteins. The BRX dom...Continue Reading

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Citations

Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Julien BeuchatChristian S Hardtke
Apr 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Stephen DepuydtChristian S Hardtke
Dec 1, 2006·Plant & Cell Physiology·Hélène BaubyJean-Christophe Palauqui
Nov 5, 2014·BMC Plant Biology·Hanneke M PeeleChristina Dixelius
Jul 12, 2008·Current Opinion in Genetics & Development·Jalean J Petricka, Philip N Benfey
Jul 24, 2010·The New Phytologist·Julien BeuchatChristian S Hardtke
Feb 6, 2015·Biotechnology & Genetic Engineering Reviews·F Malekpoor MansoorkhaniA J Thompson
Jun 11, 2009·Communicative & Integrative Biology·Jens Staal, Christina Dixelius
Jan 13, 2015·Genome Biology and Evolution·Lorenzo Carretero-PauletVictor A Albert
May 22, 2016·Seminars in Cell & Developmental Biology·Octavina C A SukartaAska Goverse
Sep 21, 2010·Current Opinion in Plant Biology·Jianming Li
Jun 30, 2016·EMBO Reports·Yeon Hee Kang, Christian S Hardtke
Jan 5, 2020·Nature Communications·Masahiko FurutaniMiyo Terao Morita
Dec 13, 2019·Development·Pietro CattaneoChristian S Hardtke
May 14, 2020·International Journal of Molecular Sciences·Cesar Augusto MedinaLong-Xi Yu
Dec 24, 2019·Developmental Cell·Petra MarhavaChristian S Hardtke
Feb 23, 2021·Frontiers in Plant Science·Zhicheng JiaoLiangfa Ge
Mar 23, 2021·The Plant Cell·Samuel W H KohChristian S Hardtke
Apr 2, 2021·Horticulture Research·Yuanyuan ZhangXiaowu Wang
May 26, 2009·Development·Emanuele ScacchiChristian S Hardtke

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