PMID: 18727208Aug 30, 2008Paper

Characterization of the porcine Kisspeptins receptor gene and evaluation as candidate for timing of puberty in sows

Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie
S LiL Huang

Abstract

Kisspeptins receptor (KISS1R), also called GPR54, is a key regulator of puberty in many species. KISS1R and its genetics in pigs remain unexplored. The objective of this study was to characterize the porcine KISS1R gene and evaluate the association of KISS1R mutations with age at puberty in sows. KISS1R was assigned to pig chromosome 2q21-24 by radiation hybrid mapping. It has a 1438 bp full-length cDNA and spans 3349 bp genomic sequence consisting of five exons and four introns. Semi-quantitative RT-PCR showed that KISS1R transcripts was particularly abundant in the adrenal, prostate, testis, thymus, pituary and hypothalamus. KISS1R mRNA content in the hypothalamus was determined by real-time quantitative RT-PCR, and it fluctuated during the oestrous cycle with the highest level in the luteal phase. Anoestrus sows had markedly lower hypothalamic KISS1R mRNA content than cyclic animals. Seven KISS1R SNPs were identified in the founder animals of a White Duroc x Erhualian intercross. One missense mutation (T/C(245)) showed quite different allele distribution in Chinese and Western breeds. All F(0), F(1) animals and 367 detailed phenotyped cyclic F(2) sows in the White Duroc x Erhualian intercross were genotyped for three KISS1R ...Continue Reading

References

Feb 1, 1981·Biology of Reproduction·H J Brinkley
Apr 1, 1999·FEBS Letters·D K LeeB F O'Dowd
Jun 2, 2001·The Journal of Biological Chemistry·A I MuirD C Harrison
Aug 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nicolas de RouxEdwin Milgrom
Oct 24, 2003·The New England Journal of Medicine·Stephanie B SeminaraWilliam H Colledge
Dec 4, 2003·Biochemical and Biophysical Research Communications·Sandrine FunesEric L Gustafson
Feb 19, 2004·Nature Reviews. Genetics·Leif Andersson, Michel Georges
Dec 16, 2004·The Journal of Clinical Endocrinology and Metabolism·R K SempleS A Aparicio
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sophie MessagerSamuel A J R Aparicio
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Muhammad ShahabTony M Plant
Oct 1, 2005·Nature Genetics·Daniel F GudbjartssonAnna Ingolfsdottir
Apr 6, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Jeremy T SmithRobert A Steiner
Dec 14, 2006·The Journal of Clinical Endocrinology and Metabolism·Yardena Tenenbaum-RakoverNicolas de Roux
Jan 9, 2007·Reviews in Endocrine & Metabolic Disorders·Wendy Kuohung, Ursula B Kaiser
Feb 27, 2007·Reviews in Endocrine & Metabolic Disorders·Waljit S DhilloStephen R Bloom
Mar 6, 2007·Reviews in Endocrine & Metabolic Disorders·Felecia Cerrato, Stephanie B Seminara
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Xavier d'Anglemont de TassignyWilliam H Colledge
Feb 15, 2008·The New England Journal of Medicine·Milena Gurgel TelesAna Claudia Latronico
Jan 1, 1986·Genetics, Selection, Evolution : GSE·M Tixier, P Sellier

❮ Previous
Next ❯

Citations

Jun 24, 2011·Molecular Biology Reports·Mingxing ChuNing Li
Sep 23, 2009·Endocrine Reviews·Amy E OakleyRobert A Steiner
Feb 27, 2013·Animal Genetics·J K TartD C Ciobanu
Oct 16, 2009·Biology of Reproduction·Junko TomikawaHiroko Tsukamura
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·C B WasikeK J Peters
Jul 19, 2019·Animal : an International Journal of Animal Bioscience·C A Lents

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved