Characterization of the prognostic values of the NDRG family in gastric cancer

Therapeutic Advances in Gastroenterology
Chaoran YuMinhua Zheng

Abstract

The N-myc downstream-regulated gene (NDRG) family, NDRG1-4, has been involved in a wide spectrum of biological functions in multiple cancers. However, their prognostic values remain sparse in gastric cancer (GC). Therefore, it is crucial to systematically investigate the prognostic values of the NDRG family in GC. The prognostic values of the NDRG family were evaluated by Kaplan-Meier Plotter and SurvExpress. The mRNA of the NDRG family was investigated in The Cancer Genome Atlas (TCGA). Transcription factors (TFs) and miRNAs associated with the NDRG family were predicted by NetworkAnalysis. The prognostic values of DNA methylation levels were analyzed by MethSurv. The correlation between immune cells and the NDRG family was evaluated by the Tumor Immune Estimation Resource (TIMER) database. High levels of mRNA expression of NDRG2 and NDRG3 were associated with a favorable prognosis in all GCs. In HER2- GC, NDRG1 was significantly associated with a poor prognosis of GC [hazard ratio (HR) = 1.65, 95% confidence interval (CI) = 1.16-2.33, p = 0.0046]. In HER2+ GC, NDRG4 showed a poor prognosis (HR = 1.4, 95% CI: 1.06-1.85, p = 0.017). NDRG4 was an independent prognostic factor in recurrence-free survival by TCGA cohort. The low-r...Continue Reading

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Citations

Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Longxiang XieXiangqian Guo
Feb 11, 2021·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Yun LiuShihe Shao
Feb 2, 2021·Oncotarget·Gina Abdelaal, Stephany Veuger
Apr 24, 2021·Asian Journal of Psychiatry·Dhruva IthalSanjeev Jain
Oct 2, 2021·Oncology Letters·Ruikai LiJianyong Zheng
Sep 10, 2020·Gastrointestinal Tumors·Melanie Tepus, Tung On Yau

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Datasets Mentioned

BETA
GSE62254
GSE51105

Methods Mentioned

BETA
protein array
ChIP-seq

Software Mentioned

TRGAted
survivalROC
GEPIA
KM plotter
Gene Expression Profiling Interactive Analysis platform ( GEPIA
survminer
R package
Graphpad Prism
MethSurv
SPSS

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