Characterization of the proportion of untreated and antiplatelet therapy treated patients with atrial fibrillation

The American Journal of Cardiology
Isla M OgilvieGregory Y H Lip

Abstract

Despite the efficacy of oral anticoagulants for stroke prevention in atrial fibrillation (AF), evidence suggests that many patients with AF who should be treated with vitamin K antagonists (VKAs) are treated with antiplatelet therapy or remain untreated. The aims of this study were to determine the proportion of patients with AF in each treatment category in clinical practice and to ascertain whether treatment is appropriate for stroke risk. An extensive search of the biomedical research published since 1994 was performed. Studies delineating the treatment of patients with AF were captured. Seventy-eight studies pertaining to the treatment of patients with AF were identified; 56 studies, containing data from 1980 to 2007, met the inclusion criteria. Over time, the use of VKA therapy for stroke prevention increased, while the proportion of untreated patients decreased; antiplatelet use remained static. Looking at the more recent data, (collected from 2000 onward), the proportion of patients receiving no therapy ranged from 4% to 48% (median 18%), antiplatelet therapy from 10% to 56% (median 30%), and VKA therapy from 9% to 86% (median 52%). Although most studies showed a decrease in the proportion of antiplatelet-treated and unt...Continue Reading

References

Aug 26, 1995·BMJ : British Medical Journal·C M SudlowR G Thomson
May 12, 1997·Archives of Internal Medicine·J H GurwitzJ Avorn
Dec 31, 1997·Stroke; a Journal of Cerebral Circulation·L M BrassM Radford
Mar 12, 1999·Lancet·R G Dalton
Nov 21, 2000·Postgraduate Medical Journal·S J McNultyK J Hardy
Nov 2, 2002·BMJ : British Medical Journal·Gregory Y H LipDwayne S G Conway
Nov 19, 2002·JAMA : the Journal of the American Medical Association·Carl van WalravenBeppie Hellemons
Jan 14, 2004·Archives of Internal Medicine·Margaret C FangDaniel E Singer
Oct 7, 2004·The American Journal of Cardiology·Colleen SamUNKNOWN Framingham Heart Study
Dec 14, 2004·Journal of Public Health·Simon de LusignanTom Chan
May 6, 2005·Journal of the American Medical Directors Association·Ahmed K Abdel-LatifBarbara J Messinger-Rapport
Nov 1, 2005·Journal of the American College of Cardiology·Albert L WaldoUNKNOWN NABOR Steering Committee
May 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi InoueKatsusuke Yano
May 30, 2006·European Heart Journal·Robby NieuwlaatUNKNOWN Euro Heart Survey Investigators
Oct 26, 2006·Pharmacoepidemiology and Drug Safety·UNKNOWN FALSTAF Study GroupN Weisslinger
Feb 14, 2007·Archives of Internal Medicine·Nicole L GlazerSusan R Heckbert
May 10, 2007·The Canadian Journal of Cardiology·Ratika ParkashDavid R Anderson
Jun 7, 2007·Internal and Emergency Medicine·D FerroF Violi
Sep 12, 2007·QJM : Monthly Journal of the Association of Physicians·M HughesUNKNOWN Guideline Development Group for the NICE national clinical guideline for management of atrial fibrillation in primary and se
Dec 1, 2007·Stroke; a Journal of Cerebral Circulation·Melina GattellariSandy Middleton
Apr 12, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Alexandre MeiltzUNKNOWN Association of Cardiologists of the Canton of Geneva
Apr 19, 2008·Stroke; a Journal of Cerebral Circulation·UNKNOWN Stroke Risk in Atrial Fibrillation Working Group
Jun 14, 2008·Scottish Medical Journal·A C CameronF G Dunn

❮ Previous
Next ❯

Citations

Mar 1, 2013·Thrombosis and Haemostasis·Raffaele De CaterinaUNKNOWN European Society of Cardiology Working Group on Thrombosis Task Force on Anticoagulants in Heart Disease
Jul 3, 2013·Trials·Derk L ArtsHenk C P M van Weert
Apr 1, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Sascha Meyer Dos Santos, Sebastian Harder
Jun 21, 2014·The American Journal of the Medical Sciences·Michael BergmanHertzel Salman
Aug 12, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A PalomäkiK E J Airaksinen
Nov 15, 2011·The American Journal of Cardiology·Basil M RuDusky
Mar 24, 2017·Thrombosis and Haemostasis·José Miguel Rivera-CaravacaFrancisco Marín
Dec 19, 2017·Journal of Atrial Fibrillation·Reza SheibaniSaeid Eslami
Mar 14, 2013·Stroke; a Journal of Cerebral Circulation·Ida Ehlers AlbertsenGregory Y H Lip
Jun 14, 2019·Journal of the American Heart Association·Inmaculada HernandezWalid F Gellad
Sep 17, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Inmaculada HernandezWalid F Gellad
Sep 17, 2013·Journal of Cardiovascular Pharmacology and Therapeutics·Pilar GallegoGregory Y H Lip

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.