Abstract
Hippocalcin is an EF-hand [Persechini A. et al. (1989) Trends Neurosci. 12, 462-467] Ca2+ binding protein encoded by a neuron-specific gene. A detailed atlas of hippocalcin messenger RNA expression in the adult rat brain was complied using in situ hybridization. Highest levels of messenger RNA are found in the hippocampus, where messenger RNA is localized in proximal dendrites of CA pyramidal cells. Expression is also seen in other brain regions, including the neocortex, caudate-putamen, taenia tecti, claustrum, olfactory tubercle, anterior olfactory nucleus, and granule cell and glomerular layers of the olfactory bulb. The rat hippocalcin gene spans approximately 9 kb and consists of three exons, separated by introns of 6.7 and 0.25 kb. Sequence analysis of the putative proximal promoter region identified two clusters of multiple E-box sites which may regulate the cell-specific expression. Two lacZ fusion constructs carrying 0.9 and 3.4 kb of rat hippocalcin gene upstream region were used to create transgenic mice. With the 3.4 kb construct, transgene expression varied between founder mice, but was always found in the dentate gyrus and CA1-CA4 regions of the hippocampus, thus partly mimicking the expression of the endogenous g...Continue Reading
References
Nov 30, 1992·Biochemical and Biophysical Research Communications·M KobayashiT Noguchi
Dec 1, 1992·Genes & Development·Y SasaiS Nakanishi
Aug 31, 1992·Biochemical and Biophysical Research Communications·A MurakamiG Inana
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S Zozulya, L Stryer
Jan 2, 1992·Gene·M BoshartB Luckow
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K TietzeE Knust
Feb 22, 1991·Science·A M DizhoorL Stryer
Nov 1, 1991·Neuron·E H MercerR D Palmiter
Dec 1, 1990·Trends in Genetics : TIG·S Henikoff
Nov 23, 1990·Science·T K Blackwell, H Weintraub
Jul 13, 1990·Neuroscience Letters·A L GundlachS P Hunt
Nov 1, 1989·Trends in Neurosciences·A PersechiniR H Kretsinger
Jun 19, 1987·Cell·P AngelM Karin
Dec 15, 1988·Nature·C C GarnerA Matus
Jan 1, 1986·Annual Review of Genetics·R D Palmiter, R L Brinster
Dec 1, 1994·Mechanisms of Development·A Bartholomä, K A Nave
Mar 1, 1995·Brain Research. Molecular Brain Research·A ChiaramelloM X Zuber
Aug 15, 1994·Neuroscience Letters·H M Johnston, B J Morris
Feb 1, 1995·Neuron·L M RobertsonT Curran
Jul 15, 1994·Brain Research. Developmental Brain Research·S SaitohT Noguchi
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·O Steward
Jul 9, 1993·Neuroscience Letters·S SaitohT Noguchi
Jan 1, 1993·Visual Neuroscience·A H MilamA M Dizhoor
Feb 5, 1993·Science·A M DizhoorJ B Hurley
Feb 1, 1993·Neuron·L E SchneiderP H Taghert
Jan 1, 1993·Annual Review of Neuroscience·G Mandel, D McKinnon
Mar 1, 1993·Neuron·M P Gray-KellerP B Detwiler
Dec 15, 1995·Genes & Development·M IshibashiF Guillemot
Nov 1, 1995·Journal of Neurogenetics·R M Twyman, E A Jones
Feb 23, 1996·Science·R FestensteinD Kioussis
Feb 1, 1996·Current Opinion in Neurobiology·A G Bang, M D Goulding
Citations
Nov 8, 2008·Cell and Tissue Research·Karl-Heinz BraunewellAndres J Klein Szanto
Dec 23, 2003·Progress in Neurobiology·Thomas Arendt
Aug 2, 2001·Journal of Neuroscience Methods·T Wells, D A Carter
Mar 12, 1998·Brain Research. Molecular Brain Research·A L Grant, W Wisden
Oct 26, 1999·Brain Research. Molecular Brain Research·Q B TianT Suzuki
Aug 12, 2000·Neuroscience·M PaterliniW Wisden
Feb 23, 2000·Neuroscience·C SpilkerK H Braunewell
Feb 5, 1999·Gene·T MasakiK Takamatsu
Nov 13, 1998·Current Opinion in Neurobiology·D Kuhl, P Skehel
Apr 25, 2000·Brain Research. Brain Research Protocols·E TakahashiK Yagami
Dec 15, 2000·The Biochemical Journal·R D Burgoyne, J L Weiss
Jul 4, 2003·Genome Research·Michel de ChaldéeJean-Marc Elalouf
Dec 28, 1999·Molecular and Cellular Biology·M E Massari, C Murre
Sep 1, 2004·Biochemical and Biophysical Research Communications·Alex MammenCheil Moon
Jan 1, 1997·Molecular and Cellular Neurosciences·A HerbP H Seeburg
Sep 14, 2004·Gastroenterology·Annie RodolosseFrancisco X Real