Characterization of the rat parotid beta-adrenoceptor

British Journal of Pharmacology
B CarlsööL A Idahl

Abstract

1 The effects of various beta-adrenoceptor agonists on amylase secretion from the rat parotid gland were studied by means of two different in vitro techniques. 2 The dose-response relation for each agonist was established, as also were the ED50 values. 3 All drugs appeared to act directly on the acinar cells, as reserpine-treatment did not abolish their secretagogic effects. 4 Two groups of agonists could be distinguished: one group consisting of adrenaline, noradrenaline and the B1-selective agonist prenalterol (H133/22) with a high enzyme discharge potency and a second group consisting of the beta 2-agonists, terbutaline and salbutamol, with a markedly lower effect. 5 The present data further support the theory that rat parotid acinar cells are supplied mainly with beta-adrenoceptors of the beta 1-subtype, similar to those present in heart and adipose tissue.

References

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Citations

Mar 12, 1985·European Journal of Pharmacology·S SundströmR Henriksson
Nov 12, 1986·European Journal of Pharmacology·J Bhattacharyya, A G Datta
Jan 12, 1988·European Journal of Pharmacology·S SundströmP Lindström
Nov 1, 1984·Journal of the Autonomic Nervous System·D Jirakulsomchok, C A Schneyer
Apr 6, 1984·Neuroscience Letters·B CarlsööR Henriksson
Mar 1, 1984·Acta Physiologica Scandinavica·B CarlsööR Henriksson
Aug 1, 1990·Acta Physiologica Scandinavica·R HenrikssonS Hellström
Oct 1, 1987·Acta Physiologica Scandinavica·G JönssonS Sundström
Jan 1, 1992·Acta Oto-laryngologica. Supplementum·H GustafssonR Henriksson
Dec 1, 1994·Journal of Dental Research·J L JensenF G Oppenheim
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G S Bedi
May 1, 1988·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·C RuellanA Ribet

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