Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine.

Cellular & Molecular Immunology
Wanbo TaiLanying Du


The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as 2019 novel coronavirus (2019-nCoV). The CoV spike (S) protein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of antibodies, entry inhibitors and vaccines. Here, we identified the receptor-binding domain (RBD) in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and, hence, attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells, thus inhibiting their infection to host cells. SARS-CoV RBD-specific antibodies could cross-react with SARS-CoV-2 RBD protein, and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2, suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection.


Oct 1, 2005·Science·Wendong LiLin-Fa Wang
Feb 10, 2009·Nature Reviews. Microbiology·Lanying DuShibo Jiang
Oct 19, 2012·The New England Journal of Medicine·Ali M ZakiRon A M Fouchier
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yang YangFang Li
Mar 18, 2016·Expert Review of Vaccines·Lanying DuShibo Jiang
Jul 30, 2016·Antiviral Research·Qihui WangGeorge F Gao
Dec 13, 2016·Expert Opinion on Therapeutic Targets·Lanying DuShibo Jiang
Jul 31, 2018·Expert Review of Vaccines·Yusen ZhouLanying Du
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 23, 2020·Lancet·Shibo JiangDeyin Guo
Mar 4, 2020·Nature Microbiology·UNKNOWN Coronaviridae Study Group of the International Committee on Taxonomy of Viruses
Apr 9, 2020·Frontiers in Microbiology·Ning WangLanying Du
Apr 30, 2020·The Pediatric Infectious Disease Journal·Despoina GkentziGabriel Dimitriou
May 19, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Luciana K TannoPascal Demoly

❮ Previous
Next ❯


Apr 11, 2020·Physiological Genomics·Rachel M GolonkaMatam Vijay-Kumar
May 13, 2020·Journal of the American Heart Association·Anthony S LarsonWaleed Brinjikji
Apr 30, 2020·Nature Reviews. Immunology·Matthew Zirui TayLisa F P Ng
Apr 30, 2020·Journal of the Chinese Medical Association : JCMA·Tai-Jay ChangChin-Tien Wang
Apr 27, 2020·Diabetes/metabolism Research and Reviews·Rocky Strollo, Paolo Pozzilli
Jun 7, 2020·Critical Reviews in Clinical Laboratory Sciences·Giovanni PontiTomris Ozben
Jun 3, 2020·International Journal of Molecular Sciences·Xinling WangShibo Jiang
Jun 23, 2020·Future Medicinal Chemistry·Siddhi JoshiMariam S Degani
Jul 4, 2020·Journal of Biomolecular Structure & Dynamics·Richa BhatnagerAmita S Dang
May 15, 2020·European Journal of Clinical Investigation·Wiktor SmykMarcin Krawczyk
Jul 8, 2020·Pathogens·Ahmed S Abdel-Moneim, Elsayed M Abdelwhab
Jul 16, 2020·The Korean Journal of Internal Medicine·Jihyang Lim, Jehoon Lee
May 18, 2020·Clinical Medicine : Journal of the Royal College of Physicians of London·Beattie Rh SturrockTimothy Jt Chevassut
Jul 22, 2020·Journal of Biomolecular Structure & Dynamics·Devashan NaidooAkash Anandraj
Jul 14, 2020·Pharmacology Research & Perspectives·Cássia L BragaPedro L Silva
Jul 30, 2020·PLoS Neglected Tropical Diseases·Peter J Hotez, Maria Elena Bottazzi
Jul 2, 2020·The Journal of Applied Laboratory Medicine·Alan H B Wu
Jun 23, 2020·European Journal of Gastroenterology & Hepatology·Pujitha KudaravalliSavio John
Aug 4, 2020·Expert Opinion on Biological Therapy·Khan SharunKuldeep Dhama
Jul 15, 2020·Nature Nanotechnology·Helena F FlorindoRonit Satchi-Fainaro
Jun 28, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wafaa B AlsoussiAli H Ellebedy
Jul 24, 2020·Journal of Drug Targeting·Saghir AkhtarAbdella M Habib
Aug 19, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Omalla A OlwenyiSiddappa N Byrareddy
Aug 19, 2020·Briefings in Bioinformatics·Krishan GuptaGaurav Ahuja
Aug 26, 2020·Pathogens and Disease·Jitendra Singh Rathore, Chaitali Ghosh
Sep 3, 2020·The New England Journal of Medicine·Cheryl KeechGregory M Glenn
Sep 5, 2020·Seminars in Liver Disease·Maria J Lizardo-ThiebaudNalu Navarro-Alvarez
Sep 6, 2020·Pharmacological Reports : PR·Thakur Uttam SinghRaj Kumar Singh
Sep 10, 2020·PLoS Pathogens·Lien Anh Ha DoPaul V Licciardi
Sep 15, 2020·Briefings in Bioinformatics·Wenzhong Yang, Guangxu Jin
Jul 30, 2020·The Journal of Pharmacology and Experimental Therapeutics·Zeenat A ShyrWei Zheng

❮ Previous
Next ❯

Datasets Mentioned


Methods Mentioned

flow cytometry

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.