Characterization of the receptor mediating the antianaphylactic effects of beta-adrenoceptor agonists in human lung tissue in vitro

British Journal of Pharmacology
P R ButchersA Wheeldon

Abstract

1 The rank order of potency of six beta-adrenoceptor agonists as inhibitors of the anaphylactic release of histamine from fragments of passively sensitized human lung in vitro was (--)-isoprenaline greater than (--) -adrenaline greater than (+/-)-salbutamol greater than (--)-noradrenaline greater than R0363 greater than H133/22. 2 The beta-adrenoceptor antagonists, propranolol, atenolol and H35/25, blocked the response to both (--)-isoprenaline and (+/-)-salbutamol competitively. Each antagonist gave similar pA2 values with both agonists. pA2 values were consistently at the high end of the range expected for interaction at a beta 2-adrenoceptor. 3 Practolol did not antagonize isoprenaline in a competitive manner but was a competitive antagonist of salbutamol with a pA2 at the high end of the range expected for interaction at a beta 2-adrenoceptor. 4 Data obtained with agonists are consistent with the receptor being of the beta 2-subtype. Data obtained with antagonists indicate a consistently higher affinity for the receptor than observed for the beta 2-subtype in other tissues but do not suggest a novel beta-adrenoceptor subtype on the mast cell of the human lung.

References

Jan 1, 1977·British Journal of Pharmacology·M E Conolly, J K Greenacre
Jan 1, 1977·British Journal of Pharmacology·A J Coleman, A R Somerville
Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
Nov 15, 1978·European Journal of Pharmacology·C RaperD Iakovidis
Jan 1, 1975·European Journal of Pharmacology·E Malta, C Raper
Jan 1, 1979·International Archives of Allergy and Applied Immunology·K Forsberg, L Sörenby
Aug 1, 1971·British Journal of Pharmacology·E S Assem, H O Schild
Sep 1, 1972·The Journal of Experimental Medicine·M KalinerK F Austen
Oct 17, 1973·Nature: New Biology·J AugsteinM L Tattersall
Jan 1, 1968·British Journal of Pharmacology and Chemotherapy·D Dunlop, R G Shanks
Feb 1, 1969·European Journal of Pharmacology·B Levy, B E Wilkenfeld
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD

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Citations

Dec 1, 1985·Agents and Actions·P O Ogunbiyi, P Eyre
Nov 30, 1989·The New England Journal of Medicine·P J Barnes
Mar 1, 1988·Clinical Allergy·J B WarrenR W Fuller
Jan 1, 1987·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P Gautheron, M F Sugrue
Nov 1, 1993·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·H TsudaH Mikawa
Nov 1, 1991·British Journal of Pharmacology·P R ButchersM Johnson
Aug 5, 1998·British Journal of Pharmacology·D E DruryP T Peachell
Apr 2, 2008·Current Allergy and Asthma Reports·David M Lang
Aug 4, 2004·British Journal of Pharmacology·Anne-Marie ScolaPeter T Peachell
Dec 10, 2003·British Journal of Pharmacology·Anne-Marie ScolaPeter T Peachell
Jan 7, 2009·Therapeutic Advances in Respiratory Disease·Mario Cazzola, Maria Gabriella Matera
Oct 1, 1988·Scottish Medical Journal·P J Howard, M R Lee
May 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M K ChurchY Okayama
Jul 2, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Esther Márquez-SaavedraManuel Romero-Gómez
Jan 2, 1997·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·P J Barnes
Oct 1, 1991·The Journal of Pharmacy and Pharmacology·R G Van AmsterdamJ Zaagsma
Mar 10, 2021·International Journal of Circumpolar Health·Linda EklundNikolai Stenfors
Feb 28, 2002·European Journal of Pharmacology·Lee K ChongPeter T Peachell
Jan 1, 1990·Molecular Aspects of Medicine·P J Barnes

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