PMID: 9416991Aug 15, 1997Paper

Characterization of the receptor response for the neuropeptide Y-evoked suppression of parasympathetically-mediated contractions in the guinea pig trachea

Regulatory Peptides
L Grundemar

Abstract

Neuropeptide Y (NPY) acts via several distinct receptor types. The aim of the present study was to examine which NPY receptors are coupled to inhibition of parasympathetically-mediated contractions of the isolated guinea pig trachea. Electrical field stimulation of tracheal rings evoked a rapid twitch, which was abolished by atropine (1 microM). NPY, the structurally related hormone peptide YY (PYY), the Y2 receptor agonist [Cys2, Aoc5-24, D-Cys27]NPY, as well as NPY 5-36 and NPY 13-36 evoked a concentration-dependent inhibition of the electrically-stimulated twitches. Pretreatment with the Y1 receptor-selective antagonist BIBP3226 (1 microM) failed to prevent the NPY-induced inhibition. Although less potent than NPY, the Y1 (and Y4-Y6) receptor agonist [Leu31, Pro34]NPY also inhibited the electrically-stimulated twitches. Another NPY-related peptide, pancreatic polypeptide, which recognizes Y4-Y6 receptors did not affect the stimulated twitches at concentrations up to 1 microM. However, pretreatment with the Y1 receptor-selective antagonist BIBP3226 (1 microM) virtually abolished the inhibition evoked by [Leu31, Pro34]NPY. None of the peptides affected the baseline tension and BIBP3226 (1 microM) per se did not affect the ampl...Continue Reading

References

Jan 1, 1992·British Journal of Pharmacology·L GrundemarR Håkanson
Jun 6, 1991·European Journal of Pharmacology·M G BelvisiP J Barnes
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J FuhlendorffT W Schwartz
May 1, 1989·Regulatory Peptides·E K PotterD I McCloskey
Mar 1, 1988·British Journal of Pharmacology·C D Stretton, P J Barnes
Dec 27, 1994·European Journal of Pharmacology·K RudolfH N Doods
Feb 5, 1996·European Journal of Pharmacology·A HirabayashiN Ishikawa

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Citations

Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·A CervinL Grundemar
Jul 13, 2002·The Journal of Comparative Neurology·Hideki MatsudaTomas Hökfelt

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