Characterization of the relationship between preshock state and virtual electrode polarization-induced propagated graded responses resulting in arrhythmia induction

Heart Rhythm : the Official Journal of the Heart Rhythm Society
David W BournN A Trayanova

Abstract

Studies have demonstrated that failed defibrillation shocks often are followed by an electrically quiescent period (isoelectric window); however, the underlying mechanisms remain incompletely understood. We recently suggested a new mechanism termed "virtual electrode polarization-induced propagated graded responses" (VEPiPGRs) that might play a role in the origin of the global postshock activation following the isoelectric window. The purpose of this study to elucidate the circumstances under which VEPiPGR activations originate for shocks given to paced right ventricular preparations. Specifically, we examined the dependence of VEPiPGRs on coupling interval (CI) and shock polarity and whether VEPiPGRs emerge preferentially on the epicardium or the endocardium. Simultaneous endocardial and epicardial activity in isolated right ventricular preparations (n = 4) was imaged optically following shocks of strength +/-5A. All VEPiPGRs were analyzed, and the time T from shock end to activation onset was recorded (isoelectric window is the smallest T among activations that propagated globally). VEPiPGR activations occurred for CIs in the range from 80 to 150 ms. Average duration of T was 64.5 +/- 18.15 ms, with T decreasing as CI increas...Continue Reading

References

May 13, 1998·Circulation·N ChattipakornR E Ideker
Jun 2, 1998·Journal of Cardiovascular Electrophysiology·P S ChenH S Karagueuzian
Oct 6, 2000·Journal of Cardiovascular Electrophysiology·N ChattipakornR E Ideker
Nov 9, 2001·Journal of Cardiovascular Electrophysiology·R A GrayN A Trayanova
Jul 26, 2002·Journal of Cardiovascular Electrophysiology·James Eason, Natalia Trayanova
Mar 11, 2003·Journal of Cardiovascular Electrophysiology·Nipon ChattipakornRaymond E Ideker
Jun 5, 2003·Chaos·Natalia TrayanovaFelipe Aguel
Aug 22, 2003·Journal of Cardiovascular Electrophysiology·Natalia A TrayanovaJames C Eason
Jan 21, 2004·Cardiovascular Research·Nipon ChattipakornRaymond E Ideker
Apr 21, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Raymond E IdekerNeal Kay
May 3, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Steven PoelzingDavid S Rosenbaum
Nov 24, 2005·Journal of Cardiovascular Electrophysiology·Xiangsheng ZhengRaymond E Ideker
Sep 11, 1987·Science·S Kauffman

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Citations

Dec 6, 2012·ISRN Cardiology·Natalia A Trayanova
Jun 9, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Natalia Trayanova
Jan 1, 2014·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Natalia A Trayanova, Patrick M Boyle
Dec 2, 2015·The Journal of Physiology·Natalia A Trayanova, Kelly C Chang
Jun 24, 2016·Progress in Biophysics and Molecular Biology·Hermenegild J ArevaloNatalia A Trayanova

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