Characterization of the six zebrafish clade B fibrillar procollagen genes, with evidence for evolutionarily conserved alternative splicing within the pro-alpha1(V) C-propeptide.

Matrix Biology : Journal of the International Society for Matrix Biology
G G HoffmanD S Greenspan

Abstract

Genes for tetrapod fibrillar procollagen chains can be divided into two clades, A and B, based on sequence homologies and differences in protein domain and gene structures. Although the major fibrillar collagen types I-III comprise only clade A chains, the minor fibrillar collagen types V and XI comprise both clade A chains and the clade B chains pro-alpha1(V), pro-alpha3(V), pro-alpha1(XI) and pro-alpha2(XI), in which defects can underlie various genetic connective tissue disorders. Here we characterize the clade B procollagen chains of zebrafish. We demonstrate that in contrast to the four tetrapod clade B chains, zebrafish have six clade B chains, designated here as pro-alpha1(V), pro-alpha3(V)a and b, pro-alpha1(XI)a and b, and pro-alpha2(XI), based on synteny, sequence homologies, and features of protein domain and gene structures. Spatiotemporal expression patterns are described, as are conserved and non-conserved features that provide insights into the function and evolution of the clade B chain types. Such features include differential alternative splicing of NH(2)-terminal globular sequences and the first case of a non-triple helical imperfection in the COL1 domain of a clade B, or clade A, fibrillar procollagen chain....Continue Reading

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Dec 29, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Qi YaoXue Zhong Liu
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Jul 15, 2020·Experimental Eye Research·Edgar M Espana, David E Birk
Sep 21, 2020·Matrix Biology : Journal of the International Society for Matrix Biology·Mei SunDavid E Birk
Jul 22, 2010·Gene Expression Patterns : GEP·Ming FangJulia Thom Oxford

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