Characterization of the solid-state: spectroscopic techniques

Advanced Drug Delivery Reviews
D E Bugay

Abstract

The physical characterization of pharmaceutical solids is an integral aspect of the drug development process. This review summarizes the use of solid-state spectroscopy techniques used in the physical characterization of the active pharmaceutical ingredient, excipients, physical mixtures, and the final dosage form. A brief introduction to infrared, Raman, and solid-state NMR experimental techniques are described as well as a more thorough description of qualitative and quantitative applications. The use of solid-state imaging techniques such as IR, Raman, and TOF-SIMS is also introduced to the reader.

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Citations

Apr 1, 2006·Pharmaceutical Research·Takashi KojimaYoshihisa Matsuda
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