Characterization of the spinal nucleus of the bulbocavernosus neuromuscular system in male mice lacking androgen receptor in the nervous system

Endocrinology
Kalina RaskinSakina Mhaouty-Kodja

Abstract

Motoneurons in the spinal nucleus of the bulbocavernosus (SNB) and their target bulbocavernosus (BC) and levator ani (LA) muscles play a role in male copulation and fertility. Testosterone (T) induces sexual differentiation of this SNB neuromuscular system during development and maintains its activation in adulthood. In the rat, T-induced effects mostly involve the androgen receptor (AR). However, the role of central AR in T-induced effects remains to be studied with pertinent genetic models. We addressed this question by using specific motoneuron immunolabeling and retrograde tracing in mice selectively disrupted for AR in the nervous system. This work reveals that nervous system AR is not required either for T-induced development of BC-LA muscles and perinatal sparing of SNB motoneurons from atrophy or for adult sensitivity of BC-LA muscles to T. By contrast, loss of AR expression in the nervous system resulted in SNB motoneurons having smaller somata and shorter dendrites than controls. We studied the effects of adult castration and T supplementation on SNB cell morphology in control and mutant males; these experiments showed that central AR is involved in the developmental regulation of soma size and dendritic length and in...Continue Reading

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Apr 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kalina RaskinSakina Mhaouty-Kodja

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Citations

Jan 10, 2014·The Journal of Endocrinology·Lydie NauléSakina Mhaouty-Kodja
Oct 24, 2015·Neuroscience Letters·Shunji YamadaMitsuhiro Kawata
Mar 26, 2016·Frontiers in Behavioral Neuroscience·Sara A KarlssonLars Westberg
Jul 30, 2014·Frontiers in Neuroscience·Hirotaka Sakamoto
Jan 1, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Afnan AtallahValérie Grange-Messent
Nov 26, 2019·Molecular and Cellular Endocrinology·Sakina Mhaouty-Kodja
Oct 24, 2021·Frontiers in Neuroendocrinology·Arnaud JeanHélène Hardin-Pouzet

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