PMID: 109513May 1, 1979

Characterization of the spontaneous murine B cell leukemia (BCL1). III. Evidence for monoclonality by using an anti-idiotype antibody

The Journal of Immunology : Official Journal of the American Association of Immunologists
E S VitettaS Strober

Abstract

We have raised an anti-idiotypic antibody against the cell surface IgM of the murine BCL1 tumor cells. This antiserum reacts exclusively with the IgM expressed on the tumor cells and detects a unique population of cells in the spleen and blood of the tumor-bearing mice. When these cells are stimulated in vitro with LPS, they secrete an IgM bearing the same idiotype as the cell surface Ig. These results are discussed in terms of a model for the immunotherapy of a chronic lymphocytic leukemia-like syndrome in mice.

Related Concepts

B-Lymphocytes
Clone Cells
Immunofluorescence Assay
IgM2
Immunoglobulin Idiotypes
Lambda-x Immunoglobulin
Leukemia, Experimental
Mice, Inbred BALB C
Myeloma Proteins
Receptors, Antigen, B-Cell

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