PMID: 6172447Dec 1, 1981Paper

Characterization of the suppressor cell activity in human cord blood lymphocytes

The Journal of Clinical Investigation
M A RodriguezR C Williams

Abstract

Newborn mononuclear cells are known to have increased suppressor activity when compared with adult cells. However, the precise phenotypic description of the suppressor cell subpopulation has not yet been reported. This study was designed to examine the surface markers on human cord blood cells as defined by monoclonal antibodies and to characterize cord blood mononuclear cells that suppress in vitro pokeweed mitogen-driven immunoglobulin production. The pattern of fluorescence with the 9,6-monoclonal antibody suggested either a decreased density or a partial blocking of E-receptors on cord blood lymphocytes. Otherwise, human cord and adult cells had similar proportions of T cell subpopulations. Different subsets of newborn cells isolated by a monoclonal antibody rosetting technique were tested for suppressor activity. Cord blood lymphocytes recognized by the OKT8 monoclonal antibody constituted the major functional suppressor cell subpopulation. These cells were present in both E-rosetting and non-E-rosetting populations. Removal of OKT8+ mononuclear cord blood cells abrogated most of the suppressor activity. Thus the major suppressor cell present in cord blood is an OKT8 positive lymphocyte.

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Citations

Oct 1, 1982·Journal of Clinical Immunology·H G Herrod, W R Valenski
Sep 1, 1987·Journal of Clinical Immunology·M A RodriguezN E Bianco
Jun 10, 1986·Journal of Immunological Methods·H AbeJ J Oppenheim
Jun 1, 1984·The Journal of Clinical Investigation·C B Wilson, J E Haas
Jul 1, 1984·Scandinavian Journal of Immunology·P L Tan, A Shore
Feb 26, 2005·Blood·Guillaume Darrasse-JèzeDavid Klatzmann
Nov 1, 1985·American Journal of Reproductive Immunology and Microbiology : AJRIM·H ChengG Delespesse
Dec 1, 1985·American Journal of Reproductive Immunology and Microbiology : AJRIM·N PapadogiannakisL B Olding
May 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·H Cheng, G Delespesse

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