Characterization of the symptoms of neurogenic orthostatic hypotension and their impact from a survey of patients and caregivers

BMC Neurology
Daniel O ClaassenChristopher Gibbons

Abstract

Neurogenic orthostatic hypotension (nOH) results from impaired vasoconstriction due to dysfunction of the autonomic nervous system and is commonly associated with Parkinson disease (PD), multiple system atrophy (MSA), and pure autonomic failure. nOH can increase the risk of falls due to symptoms that include postural lightheadedness or dizziness, presyncope, and syncope. The purpose of this study was to obtain information from patients and caregivers regarding the symptoms and burden of nOH to expand on limited knowledge regarding the impact of nOH on quality of life. This author-designed survey included questions regarding nOH (e.g., frequency and impact of symptoms, management) and was conducted online by Harris Poll via distribution to individuals who agreed to participate in Harris Poll online surveys or who were members of relevant disease advocacy organizations. Eligible patients were aged ≥ 18 years with PD, MSA, or pure autonomic failure and ≥ 1 of the following: orthostatic hypotension (OH), nOH, low blood pressure upon standing, or OH/nOH symptoms. Eligible caregivers cared for such patients but were not necessarily linked to any patient participant. Survey responses were received from 363 patients and 128 caregivers....Continue Reading

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Citations

Jun 4, 2019·Journal of Parkinson's Disease·Vikas KotagalNicolaas I Bohnen
Oct 11, 2019·The Journal of Clinical Hypertension·David S Cannom
Apr 8, 2020·Journal of Sleep Research·Nicholas K H ChiuElie Matar
Jul 11, 2020·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Mo-Kyung Sin, Pravin Khemani
Aug 6, 2020·Journal of Physical Therapy Science·Hironobu UzawaYusuke Nishida
Aug 29, 2019·Neurology and Therapy·Jeremy K Cutsforth-Gregory, Phillip A Low
Sep 29, 2020·Frontiers in Neurology·Katherine LongardnerIrene Litvan
Sep 19, 2020·Clinical Medicine Insights. Cardiology·Dinesh K KalraSumit Sohal
Mar 10, 2021·Current Neurology and Neuroscience Reports·Stuart H IsaacsonAmanda C Peltier
Mar 12, 2021·American Journal of Hypertension·Juan Francisco IdiaquezItalo Biaggioni
Mar 25, 2020·The American Journal of Cardiology·Brian Olshansky, James Muldowney
May 6, 2021·Wiener medizinische Wochenschrift·Gerhard Ransmayr
Aug 24, 2021·International Journal of General Medicine·Fahd AmjadAntonella Favit

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