Characterization of the systemic disease and ocular signs induced by experimental infection with Chlamydia psittaci in cats

Veterinary Microbiology
J TerWeeK J Dreier

Abstract

In addition to the commonly reported ocular signs, Chlamydia psittaci infection of kittens resulted in fever, lethargy, lameness and reduction in weight gain following ocular instillation of virulent organisms. The appearance of these systemic signs was late with respect to the appearance of ocular symptoms and occurred simultaneously with increasing levels of chlamydia-specific IgG. Measurement of acute phase reactants and IL-6 in plasma indicated that both became elevated concurrent with or slightly after the appearance of fever and remained elevated after the fever began to resolve. Preliminary data also indicated that infectious C. psittaci was present in the blood stream during this time period. The results of ocular instillation of three different levels of C. psittaci (10(3.8), 10(2.8) and 10(1.5) TCID50) indicated that the frequency of infection and the severity of ocular signs were diminished in the group receiving the lowest dose. However, the magnitude of systemic disease was similar in all animals which exhibited clinical signs, irrespective of the dose administered. The immune response to infection included elementary body (EB)-specific lymphocyte proliferation as well as the development of EB-specific IgG and IgM ...Continue Reading

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Citations

Jul 13, 2000·Veterinary Microbiology·K D Everett
Jun 28, 2001·Journal of Clinical Microbiology·C HelpsD Harbour
Jun 7, 2003·Journal of Clinical Microbiology·Chris HelpsDave Harbour
Apr 10, 2012·The Veterinary Clinics of North America. Small Animal Practice·Elizabeth M Graham, David J Taylor
Apr 7, 2009·Veterinary Microbiology·Annie Rodolakis, Khalil Yousef Mohamad
Aug 10, 2007·The Veterinary Journal·Saverio Paltrinieri
Sep 23, 2011·Veterinary Ophthalmology·Christina SibitzBarbara Nell
Aug 10, 2011·Zoonoses and Public Health·M HalánováM Holičková
Sep 18, 2001·The Journal of Veterinary Medical Science·K IwamotoM Yamanaka
Jan 10, 2003·The Journal of Veterinary Medical Science·Katsuo MasubuchiYukio Shimizu
Apr 27, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Saverio PaltrinieriGuazzetti Stefano
Jan 10, 2018·Veterinary Pathology·Nicole BorelAndreas Pospischil
May 10, 2005·Clinical and Diagnostic Laboratory Immunology·Damien P HigginsPaul J Canfield
Dec 9, 2003·Journal of Veterinary Internal Medicine·A RampazzoB Biolatti

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