Characterization of the thoracodorsal artery: morphology and reactivity.

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Marie BillaudB E Isakson

Abstract

In this paper, we describe the histological and contractile properties of the thoracodorsal artery (TDA), which indirectly feeds the spinotrapezius muscle. We used immunolabelling techniques to histologically characterize the TDA while the contractile properties were assessed using pressure arteriography. Our results demonstrate that the TDA is composed of approximately one to two layers of smooth muscle cells, is highly innervated with adrenergic nerves, and develops spontaneous tone at intraluminal pressures above 80 mmHg. The reactivity of the TDA in response to various contractile agonists such as phenylephrine, noradrenaline, angiotensin II, serotonin, endothelin 1, and ATP, as well as vasodilators, shows that the TDA exhibits a remarkably comparable reactivity to what has been observed in mesenteric arteries. We further studied the different components of the TDA response to acetylcholine, and found that the TDA was sensitive to TRAM 34, a blocker of the intermediate conductance potassium channel, which is highly suggestive of an endothelium-dependent hyperpolarization. We conclude that the TDA exhibits comparable characteristics to other current vascular models, with the additional advantage of being easily manipulated f...Continue Reading

References

Apr 1, 1967·Journal of Ultrastructure Research·J A Rhodin
Apr 1, 1994·Journal of Applied Physiology·J M Lash
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·K A DoraB R Duling
Apr 12, 2000·Acta Physiologica Scandinavica·S S Segal
Nov 19, 2002·Molecular Pharmacology·Catherine Vial, Richard J Evans
Mar 1, 2003·Histochemistry and Cell Biology·Finn GustafssonNiels-Henrik Holstein-Rathlou
Oct 30, 2003·Journal of Vascular Research·Kim A DoraChris J Garland
Sep 25, 2004·The Journal of Physiology·Shawn E BeardenSteven S Segal
Apr 13, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Walter L MurfeeShayn M Peirce
Jun 25, 2005·Vascular Pharmacology·Alex A Pérez-RiveraJames J Galligan
Oct 21, 2005·The Journal of Pharmacology and Experimental Therapeutics·Yukako HatanakaHiromu Kawasaki
Apr 22, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Walter L MurfeeThomas C Skalak
Jul 26, 2006·Hypertension·Maria Carolina GongoraDavid G Harrison
Dec 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Eun A KoErnesto L Schiffrin
Jan 16, 2007·Circulation Research·Brant E IsaksonBrian R Duling
Jul 10, 2007·Cardiovascular Research·Gábor FésüsMaik Gollasch
Jul 13, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shawn E Bearden
May 2, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robin C Looft-WilsonShawn E Bearden
Jun 25, 2008·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Alexander M BaileyShayn M Peirce
Nov 21, 2008·Clinical and Experimental Pharmacology & Physiology·Shaun L SandowFrances Plane
Dec 18, 2008·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M C J de WithM Kon
Mar 31, 2009·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Katherine R HeberleinBrant E Isakson
May 9, 2009·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Simon J PotocnikMichael A Hill
Jul 31, 2009·Cardiovascular Research·Gilles KauffensteinJean Sévigny

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Citations

Oct 9, 2013·Molecular and Cellular Biochemistry·Neeta AdhikariJennifer L Hall
Jun 9, 2012·Cardiovascular Research·Alexander W LohmanBrant E Isakson
Sep 24, 2015·Cellular and Molecular Life Sciences : CMLS·Xiaohong ShuBrant E Isakson
Nov 26, 2015·European Journal of Pharmacology·James A Angus, Christine E Wright
May 17, 2014·Free Radical Biology & Medicine·Joshua T ButcherBrant E Isakson
Feb 1, 2015·European Journal of Pharmacology·James A AngusChristine E Wright
Mar 12, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Brittany G DurginJessica J Connelly
Apr 11, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Ryan M HaskinsGary K Owens
Dec 15, 2017·Circulation Research·Miranda E GoodKodi S Ravichandran
Jul 22, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Leon J DeLalioBrant E Isakson
Sep 1, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Sanchita BasuAaron Proweller
Mar 23, 2019·Circulation Research·Xiaohong ShuBrant E Isakson
Mar 1, 2019·The Journal of Biological Chemistry·Leon J DeLalioBrant E Isakson
Jan 1, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Norman E FrederickPooneh Bagher
Apr 4, 2019·American Journal of Physiology. Renal Physiology·Jing LiWeibin Shi
Mar 29, 2014·Pharmacological Reviews·Marie BillaudBrant E Isakson
Sep 10, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Nivedita K NareshFrederick H Epstein
Dec 6, 2019·Circulation Research·Nenja KrügerBrant E Isakson
Jun 13, 2020·Frontiers in Endocrinology·Miguel Martin-Aragon BaudelManuel F Navedo
Oct 9, 2018·The Journal of Clinical Investigation·Christophe LechauveMitchell J Weiss
May 11, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ashish K SharmaVictor E Laubach
May 15, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Camilla F WenceslauR Clinton Webb

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