Characterization of the two H1(zero)-encoding genes from Xenopus laevis

Gene
M P BrocardS Khochbin

Abstract

We have analyzed the promoter and the coding sequences of the two homologous histone H1(zero)-encoding genes from Xenopus laevis, here termed H1(zero)-1 and H1(zero)-2. Both genes encode proteins of 193 amino acids and differ at just 16 amino-acid residues. Putative regulatory sequences identified in the promoter region are the same and are highly conserved. However, significant differences exist in the 5' untranslated regions (UTR) of the transcribed sequences of these two genes, such as several deletions in the 5'-UTR of the H1(zero)-2 gene in comparison with the H1(zero)-1 gene 5'-UTR. The 3'-UTR is a short sequence of about 200 bp which is unexpected compared with the long 3'-UTR of mammalian H1(zero) mRNA, but it is in the same size range as in avian H5 mRNA. Thus, the main differences between these two genes are observed in sequences potentially involved in the regulation of the H1(zero) gene expression such as the 5'-UTR. The two genes are expressed during embryogenesis and in several adult tissues. We discuss these findings in terms of the evolution of histone H1(zero) genes in vertebrates and the appearance of histone H5 in avian species.

References

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Citations

Jun 2, 2012·Epigenetics & Chromatin·Paul B TalbertSteven Henikoff
Mar 27, 2012·Journal of Molecular Biology·Christine ÖbergSergey Belikov
Sep 12, 2002·The Journal of Biological Chemistry·Elisavet KoutzamaniIngemar Rundquist
May 26, 2017·Cellular & Molecular Biology Letters·Andrzej Kowalski
Oct 4, 2018·Frontiers of Medicine·Tao WangSaadi Khochbin

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