Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice

Acta Tropica
Luciana M SilvaZ A Andrade

Abstract

Mice chronically infected with Schistosoma mansoni develop one of two anatomical forms of hepatic lesions: severe, periportal (pipestem) fibrosis or milder, isolated granulomas. The pathogenesis of periportal fibrosis is poorly understood. In this work we compared mice with either periportal fibrosis or isolated granulomas to identify specific markers of severe pathology. BALB/c or Swiss Webster mice were infected with 30 cercarie, once or six times, and liver biopsies were performed to classify the animals into two pathological groups 16 weeks later. Sixty percent of the animals sacrificed at 20 or 24 weeks had periportal fibrosis, 15-20% had isolated granulomas and the remainder had indeterminate pathology. There was no correlation between frequency of infections or egg burden (eggs/gliver) at 20 and 24 weeks post-infection and the development of periportal fibrosis. Livers with periportal fibrosis at 20 or 24 weeks of infection were characterized by larger areas of fibrotic tissue and greater vascularization compared to livers of mice with isolated granulomas. Plastic casts of the portal vein system showed marked changes in vascular structure in mice with periportal fibrosis, including collateral vessels sprouting from the m...Continue Reading

References

May 5, 1998·Memórias do Instituto Oswaldo Cruz·Z A AndradeM M de Souza
Oct 16, 2004·Memórias do Instituto Oswaldo Cruz·Zilton A Andrade

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Citations

Jan 15, 2011·Parasitology·Roger D DennisChristian Bauer
Feb 8, 2011·Experimental Parasitology·F ShariatiA Muro
Aug 20, 2010·Memórias do Instituto Oswaldo Cruz·Zilton A Andrade, Thaynã Souto Santana
Nov 10, 2007·Memórias do Instituto Oswaldo Cruz·Camila Bião LimaZilton A Andrade

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