Characterization of the vasodilator properties of peroxynitrite on rat pulmonary artery: role of poly (adenosine 5'-diphosphoribose) synthase

British Journal of Pharmacology
F ChabotT W Evans

Abstract

1. The pulmonary vasculature is constantly exposed to oxygen and reactive oxygen species such as nitric oxide (NO) and superoxide anions which can combine at a near diffusion limited rate, to form the powerful, oxidant, peroxynitrite (ONOO-). When formed in large amounts, ONOO- is thought to contribute to tissue injury and vascular dysfunction seen in diseases such as the acute respiratory distress syndrome (ARDS) and septic shock. Recent studies have shown that ONOO- can cause vasodilatation and at higher concentrations can activate poly (adenosine 5'-diphosphoribose) synthase (PARS) leading to consumption of nicotinamide adenine dinucleotide (NAD+) and adenosine 5'-triphosphate (ATP). As the lung represents a prime site for ONOO- formation, we characterized its effects on pulmonary vascular tone and on endothelial function. In addition, we have assessed the role of PARS in producing the vasoactive properties of ONOO- on pulmonary artery rings. 2. Isolated pulmonary artery rings from rats were mounted in organ baths containing warmed and gassed (95% O2: 5% CO2) Krebs buffer. Force was measured with isometric force transducers. After equilibration, ONOO- (10 nM-100 microM) was added in a cumulative manner. In separate experimen...Continue Reading

References

Aug 1, 1991·European Journal of Clinical Investigation·S Moncada, E A Higgs
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J S PollockF Murad
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Mar 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·V V Patwardhan, A Lanthier
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A MoroS Moncada
Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·N W KooyJ S Beckman
May 25, 1995·Biochemical and Biophysical Research Communications·M G SalgoW A Pryor
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·L M VillaS Moncada
Jan 1, 1994·Archives of Biochemistry and Biophysics·R RadiR Telleri

❮ Previous
Next ❯

Citations

Apr 17, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Arnaud MansartZoë L S Brookes
Sep 24, 2002·Pharmacology & Therapeutics·B J Nevin, K J Broadley
Sep 27, 2002·Toxicology·C K Chow, C B Hong
May 22, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·D PellegrinoB Tota
Apr 10, 2002·Critical Care Medicine·Penglin Ma, Robert L Danner
Jul 25, 2007·Clinical and Experimental Pharmacology & Physiology·Rao M UppuPhilip J Kadowitz
Apr 29, 1998·Pharmacology & Toxicology·A T DemiryürekI Kanzik
Mar 29, 2012·Canadian Journal of Physiology and Pharmacology·David B CaseyPhilip J Kadowitz
Aug 31, 2010·Respiratory Physiology & Neurobiology·Michelle J Connolly, Philip I Aaronson
Sep 1, 2000·The American Journal of Medicine·P Kubes, D M McCafferty
Sep 30, 2004·Free Radical Biology & Medicine·Jaques BelikA Keith Tanswell
Jan 10, 2002·Pulmonary Pharmacology & Therapeutics·P A Henricks, F P Nijkamp
Oct 12, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·N N TuranH Celebi
Jul 22, 2010·Free Radical Biology & Medicine·Azhar MasoodA Keith Tanswell
Oct 16, 1999·Anesthesiology·W SteudelW M Zapol
Dec 1, 2007·Journal of Cardiovascular Pharmacology·Bobby D NossamanPhilip J Kadowitz
Apr 30, 2008·Current Opinion in Anaesthesiology·Domokos Gerö, Csaba Szabó
Mar 27, 2003·Current Opinion in Critical Care·Lucas Liaudet, Mauro Oddo
Feb 15, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Lucas Liaudet
Aug 24, 2000·Journal of Applied Physiology·R IturriagaM Mosqueira
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A K BrzezinskaS J Elliott
Jan 13, 2004·Journal of Applied Physiology·B D NossamanP J Kadowitz
Oct 12, 1999·The American Journal of Physiology·E J PulidoR C McIntyre
Nov 14, 1998·The American Journal of Physiology·S J ElliottA K Brzezinska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.